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A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but its presence and variability in the human(More)
Studies of gene expression abnormalities in psychiatric or neurological disorders often involve the use of postmortem brain tissue. Compared with single-cell organisms or clonal cell lines, the biological environment and medical history of human subjects cannot be controlled, and are often difficult to document fully. The chance of finding significant and(More)
There are major concerns that specific agonal conditions, including coma and hypoxia, might affect ribonucleic acid (RNA) integrity in postmortem brain studies. We report that agonal factors significantly affect RNA integrity and have a major impact on gene expression profiles in microarrays. In contrast to agonal factors, gender, age, and postmortem(More)
In this paper we first introduce the concepts of utilisation ratio and effective speedup and their relations to the system performance. We then describe a two-level scheduling scheme which can be used to achieve good performance for parallel jobs and good response for interactive sequential jobs and also to balance both parallel and sequential workloads.(More)
INEX investigates focused retrieval from structured documents by providing large test collections of structured documents, uniform evaluation measures, and a forum for organizations to compare their results. This paper reports on the INEX 2014 evaluation campaign, which consisted of three tracks: The Interactive Social Book Search Track investigated user(More)
BACKGROUND Gene expression patterns in the brain are strongly influenced by the severity and duration of physiological stress at the time of death. This agonal effect, if not well controlled, can lead to spurious findings and diminished statistical power in case-control comparisons. While some recent studies match samples by tissue pH and clinically(More)
We report the implementation of a scheduling method which combines time sharing and space sharing on AP/Linux. To run many tasks simultaneously on a parallel computer, the parallel computer system needs a partitioning algorithm that can partition processors for incoming tasks. However, a typical problem for the algorithm is a blockade situation, which(More)
Users looking for books online are confronted with both professional meta-data and user-generated content. The goal of the Interactive Social Book Search Track was to investigate how users used these two sources of information, when looking for books in a leisure context. To this end participants recruited by four teams performed two different tasks using(More)