David W. H. Riches

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ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking.

Surinder M Soond, Bethany Everson, David W. H. Riches, Gillian Murphy
Journal of cell science
2005

Tumor necrosis factor alpha-converting enzyme (TACE/ADAM17) has been implicated in the inducible shedding of numerous cell surface proteins. In light of this, the regulation of TACE catalytic… (More)

Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes.

Claudia V. Jakubzick, Emmanuel L. Gautier, +16 authors Gwendalyn J Randolph
Immunity
2013

It is thought that monocytes rapidly differentiate to macrophages or dendritic cells (DCs) upon leaving blood. Here we have shown that Ly-6C⁺ monocytes constitutively trafficked into skin, lung, and… (More)

Early pulmonary inflammation in infants with cystic fibrosis.

Talat Z Khan, Jeffrey S. Wagener, Thomas W Bost, Javier A. Martinez, Frank Accurso, David W. H. Riches
American journal of respiratory and critical care…
1995

The mechanisms underlying the initiation of lung disease and early respiratory morbidity in cystic fibrosis (CF) are poorly understood. By identifying infants with CF through a statewide neonatal… (More)

Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1.

Yong Zhang, Donald Y. M. Leung, +4 authors Elena Goleva
Journal of immunology
2012

It is estimated that 1 billion people around the world are vitamin D deficient. Vitamin D deficiency has been linked to various inflammatory diseases. However, the mechanism by which vitamin D… (More)

Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kappaB signaling pathways.

Edward D. Chan, Kristin R Morris, +4 authors David W. H. Riches
Infection and immunity
2001

Nitric oxide (NO*) expression by inducible nitric oxide synthase (iNOS) is an important host defense mechanism against Mycobacterium tuberculosis in mononuclear phagocytes. The objective of this… (More)

Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages.

Paul W. Noble, Fiona R Lake, Peter M Henson, David W. H. Riches
The Journal of clinical investigation
1993

Macrophages participate in inflammatory and repair processes in part through the selective release of cytokines that contribute to tissue remodeling. Extracellular matrix components generated at… (More)

Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways.

Shoken Honsho, Susumu Nishikawa, +12 authors Hiroaki Matsubara
Circulation research
2009

RATIONALE It has been reported that interleukin (IL)-1 is associated with pathological cardiac remodeling and LV dilatation, whereas IL-1beta has also been shown to induce cardiomyocyte hypertrophy.… (More)

Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages.

Edward D. Chan, Brent Winston, Soo Tack Uh, Murry W. Wynes, David Rose, David W. H. Riches
Journal of immunology
1999

The expression of inducible nitric oxide synthase (iNOS) by macrophages is stimulated by coexposure to IFN-gamma and a number of stimuli, including TNF-alpha. Recent work has shown that TNF-alpha… (More)

Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4.

Ruby F Fernandez-Boyanapalli, S. Courtney Frasch, +5 authors Donna L. Bratton
Blood
2009

Chronic granulomatous disease (CGD) is characterized by overexuberant inflammation and autoimmunity that are attributed to deficient anti-inflammatory signaling. Although regulation of these… (More)

IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line.

Edward D. Chan, David W. H. Riches
American journal of physiology. Cell physiology
2001

Nitric oxide (NO.) produced by inducible nitric oxide synthase (iNOS) mediates a number of important physiological and pathophysiological processes. The objective of this investigation was to examine… (More)

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