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- Yong Zhang, Donald Y. M. Leung, +4 authors Elena Goleva
- Journal of immunology
- 2012
It is estimated that 1 billion people around the world are vitamin D deficient. Vitamin D deficiency has been linked to various inflammatory diseases. However, the mechanism by which vitamin D… (More)
- Talat Z. Khan, Jeffrey S. Wagener, Thomas W. Bost, Javier A. Martinez, Frank Accurso, David W. H. Riches
- American journal of respiratory and critical care…
- 1995
The mechanisms underlying the initiation of lung disease and early respiratory morbidity in cystic fibrosis (CF) are poorly understood. By identifying infants with CF through a statewide neonatal… (More)
- Edward D. Chan, Kristin R Morris, +4 authors David W. H. Riches
- Infection and immunity
- 2001
Nitric oxide (NO*) expression by inducible nitric oxide synthase (iNOS) is an important host defense mechanism against Mycobacterium tuberculosis in mononuclear phagocytes. The objective of this… (More)
- Surinder M Soond, Bethany Everson, David W. H. Riches, Gillian Murphy
- Journal of cell science
- 2005
Tumor necrosis factor alpha-converting enzyme (TACE/ADAM17) has been implicated in the inducible shedding of numerous cell surface proteins. In light of this, the regulation of TACE catalytic… (More)
- Paul W. Noble, Fiona R Lake, Peter M Henson, David W. H. Riches
- The Journal of clinical investigation
- 1993
Macrophages participate in inflammatory and repair processes in part through the selective release of cytokines that contribute to tissue remodeling. Extracellular matrix components generated at… (More)
- Edward D. Chan, David W. H. Riches
- American journal of physiology. Cell physiology
- 2001
Nitric oxide (NO.) produced by inducible nitric oxide synthase (iNOS) mediates a number of important physiological and pathophysiological processes. The objective of this investigation was to examine… (More)
- Claudia V. Jakubzick, Emmanuel L. Gautier, +16 authors Gwendalyn J Randolph
- Immunity
- 2013
It is thought that monocytes rapidly differentiate to macrophages or dendritic cells (DCs) upon leaving blood. Here we have shown that Ly-6C⁺ monocytes constitutively trafficked into skin, lung, and… (More)
- Philippe C Carré, R. L. Mortenson, Talmadge E. King, Paul W. Noble, C L Sable, David W. H. Riches
- The Journal of clinical investigation
- 1991
Neutrophil migration into the airspaces of the lung is thought to contribute to the alveolar damage and subsequent fibrosis in idiopathic pulmonary fibrosis (IPF). Interleukin 8 (IL-8), a monocyte-… (More)
Autophagy variation within a cell population determines cell fate via selective degradation of Fap-1
- Jacob M. Gump, Leah Staskiewicz, Michael J. Morgan, Alison Bamberg, David W. H. Riches, Andrew M. Thorburn
- Nature Cell Biology
- 2014
Autophagy regulates cell death both positively and negatively, but the molecular basis for this paradox remains inadequately characterized. We demonstrate here that transient cell-to-cell variations… (More)
- Brian B Graham, Margaret M. Mentink-Kane, +11 authors Rubin M. Tuder
- The American journal of pathology
- 2010
The mechanisms underlying schistosomiasis-induced pulmonary hypertension (PH), one of the most common causes of PH worldwide, remain unclear. We sought to determine whether Schistosoma mansoni causes… (More)