David W. Yesair

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PURPOSE Fenretinide [N-(4-hydroxyphenyl)retinamide (4-HPR)] is a cytotoxic retinoid that suffers from a wide interpatient variation in bioavailability when delivered orally in a corn oil capsule. The poor bioavailability of the capsule formulation may have limited responses in clinical trials, and the large capsules are not suitable for young children. To(More)
The isolation and purification of at least two distinct macro-molecular lipids from murine L1210 tumors either sensitive or resistant to the terephthalanilide NSC 38280 are described. The lipids are extracted from the tumors with chlorofornrmeth-anol and purified utilizing a series of gel permeation and affinity chromatography columns with(More)
The physiological disposition of N-(phosphonacetyl)-L-aspartate (NSC 224131; PALA), a potent inhibitor of aspartate transcarbamylase, has been studied in mouse, rat, dog, and monkey after administration of [14C]PALA at 120 mg/sq m i.v. or p.o. Concentrations of PALA equivalents in plasma, urine, and feces were determined radiochemically, and urine was(More)
The United States Environmental Protection Agency (EPA) is sponsoring research on the development of Pharmacokinetic Models to support the Agency's Exposure and Risk Assessment processes. A prototype model, formulated for the chemical hexachlorobenzene (HCB), has been developed to describe this chemical's absorption, distribution, and elimination in humans(More)
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