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PURPOSE Fenretinide [N-(4-hydroxyphenyl)retinamide (4-HPR)] is a cytotoxic retinoid that suffers from a wide interpatient variation in bioavailability when delivered orally in a corn oil capsule. The poor bioavailability of the capsule formulation may have limited responses in clinical trials, and the large capsules are not suitable for young children. To(More)
The United States Environmental Protection Agency (EPA) is sponsoring research on the development of Pharmacokinetic Models to support the Agency's Exposure and Risk Assessment processes. A prototype model, formulated for the chemical hexachlorobenzene (HCB), has been developed to describe this chemical's absorption, distribution, and elimination in humans(More)
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