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OBJECTIVE To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS). RESEARCH DESIGN AND METHODS DPP/DPPOS participants were assessed for diabetes every 6 months and for antidepressant use every 3 months in DPP and every(More)
Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32(More)
Language run-time systems are often called upon to safely execute mutually distrustful tasks within the same runtime, protecting them from other tasks' bugs or otherwise hostile behavior. Well-studied access controls exist in systems such as Java to prevent unauthorized reading or writing of data, but techniques to measure and control resource usage are(More)
A representative democracy depends on a universally trusted voting system for the election of representatives; voters need to believe that their votes count, and all parties need to be convinced that the winner and loser of the election were declared legitimately. Direct recording electronic (DRE) voting systems are increasingly being deployed to fill this(More)
OBJECTIVE Glycated hemoglobin (HbA1c), a standard measure of chronic glycemia for managing diabetes, has been proposed to diagnose diabetes and identify people at risk. The Diabetes Prevention Program (DPP) was a 3.2-year randomized clinical trial of preventing type 2 diabetes with a 10-year follow-up study, the DPP Outcomes Study (DPPOS). We evaluated(More)
OBJECTIVE To determine whether depression symptoms or antidepressant medication use predicts weight regain in overweight individuals with impaired glucose tolerance (IGT) who are successful with initial weight loss. RESEARCH DESIGN AND METHODS A total of 1,442 participants who successfully lost at least 3% of their baseline body weight after 12 months of(More)
OBJECTIVE To assess in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study whether diagnosis of diabetes predicted elevated depressive symptoms (DS) or use of antidepressant medicine (ADM) following diagnosis; whether diabetes status or duration had significant effect on DS or ADM use; and to determine the associations between(More)
et al. The Pathways study: a randomized trial of collaborative care in patients with diabetes and depression. Q Does an individualised treatment programme improve depression in people with depression and diabetes mellitus? METHODS Design: Randomised controlled trial. Patients: 329 people with diabetes mellitus and comorbid depression with or without(More)
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