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OBJECTIVE To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS). RESEARCH DESIGN AND METHODS DPP/DPPOS participants were assessed for diabetes every 6 months and for antidepressant use every 3 months in DPP and every(More)
T he democratic process rests on a fair, universally accessible voting system through which all citizens can easily and accurately cast a vote. With the 2000 US presidential election, however, the country got a firsthand look at the results of a flawed voting system, which fueled renewed public interest in voting system reliability. People became especially(More)
Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32(More)
Language run-time systems are often called upon to safely execute mutually distrustful tasks within the same runtime, protecting them from other tasks' bugs or otherwise hostile behavior. Well-studied access controls exist in systems such as Java to prevent unauthorized reading or writing of data, but techniques to measure and control resource usage are(More)
OBJECTIVE Glycated hemoglobin (HbA1c), a standard measure of chronic glycemia for managing diabetes, has been proposed to diagnose diabetes and identify people at risk. The Diabetes Prevention Program (DPP) was a 3.2-year randomized clinical trial of preventing type 2 diabetes with a 10-year follow-up study, the DPP Outcomes Study (DPPOS). We evaluated(More)
OBJECTIVE To determine whether depression symptoms or antidepressant medication use predicts weight regain in overweight individuals with impaired glucose tolerance (IGT) who are successful with initial weight loss. RESEARCH DESIGN AND METHODS A total of 1,442 participants who successfully lost at least 3% of their baseline body weight after 12 months of(More)
No student ever had his entire education ruined because of a learning innovation that didn't come off. But I can show you plenty of students whose curiosity and imagination were strangled by being trapped in a repetitive, uninspiring, unimaginative learning enclosure. The Purdue Polytechnic Institute is an educational initiative aimed at creating an(More)
BACKGROUND Derived from multiple disciplines and established in industries outside of medicine, Implementation Science (IS) seeks to move evidence-based approaches into widespread use to enable improved outcomes to be realized as quickly as possible by as many as possible. METHODS This review highlights selected IS theories and models, chosen based on the(More)
The Interprofessional Resource Centre (IRC) was based on an extensive literature search and a provincial consultative process that involved administrators, health care providers, educators, preceptors, and alternative and complementary health care providers from different disciplines. Information from the literature review was synthesized into a logic model(More)
BACKGROUND Implementation science (IS) is the study of methods that successfully integrate best evidence into practice. Although typically applied in healthcare settings to improve patient care and subsequent outcomes, IS also has immediate and practical applications to medical education toward improving physician training and educational outcomes. The(More)