David W Lahti

Learn More
We tested the chemopreventive efficacy of indole-3-carbinol (I3C), a constituent of Brassica vegetables, and its major condensation product, 3,3'-diindolylmethane (DIM), against lung tumorigenesis induced by a mixture of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (BaP) in A/J mice. The mixture of NNK plus BaP (2 micromol each)(More)
The utility of scintigraphic views obtained after administration of sodium bicarbonate-citric acid-simethicone crystals (E-Z-GAS) for the determination of gastric extrahepatic perfusion was evaluated in 20 technetium-99m macroaggregated albumin hepatic arterial perfusion studies performed in 19 patients. These crystals produce carbon dioxide gas, distend(More)
Using immunological approaches and mass spectrometry, five proteins associated with metallothionein-3 in mouse brains have been identified. Metallothionein-3 and associated proteins were isolated using immunoaffinity chromatography over immobilized anti-mouse brain MT3 antibody. Proteins in the recovered pool were separated by SDS-polyacrylamide gel(More)
We have previously generated convincing evidence that combinations of N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine (PEITC-NAC; 3 micromol/g diet) and myo-inositol (MI; 56 micromol/g diet) were significantly more effective than the individual compounds as inhibitors of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice. In this study, we(More)
Dialkyl and diaryl sulfoxides are oxidized to sulfones by hydrogen peroxide using methyltrioxorhenium as the catalyst. The reaction rate is negligible without a catalyst. The kinetics study was performed in CH3CN-H2O (4:1 v/v) at 298 K with [H+] at 0.1 M, conditions which make the equilibration between MTO and its peroxo complexes more rapid than the(More)
603r PowerPC single board computer SEU rate predictions are compared to on-orbit CALIPSO data. Upset mitigation includes hardware voting 3 or 4 processors with transparent system upset monitoring and recovery. The 7447A PowerPC (G4) radiation performance is also reported.
David Lahti joined the Biology Department in fall 2009. He is unique in the department not only because of his research field, animal behavior, but because he holds two doctoral degrees: a PhD in Ecology and Evolutionary Biology from the University of Michigan and a PhD in Moral Philosophy and Philosophy of Biology from the Whitefield Institute at Oxford,(More)
A new tridentate ligand, PYAN, is employed to investigate solvent influences for dioxygen reactivity with [Cu(PYAN)(MeCN)]B(C(6)F(5))(4) (1). Stopped-flow kinetic studies confirm that the adducts [[u(II)(PYAN)]2)(O(2))][B(C(6)F(5))(4)](2) (2(Peroxo)) and [[u(III)(PYAN)]2)(O)(2)][B(C(6)F(5))(4)](2) (2(Oxo)) are in rapid equilibrium. Thermodynamic parameters(More)
Two new oxorhenium(V) compounds were prepared and characterized: MeReO(mtp)(Me(2)Bpy) and MeReO(mtp)(dppb), where mtpH(2) is 2-(mercaptomethyl)thiophenol, Me(2)Bpy is 4,4'-dimethyl-2,2'-bipyridine, and dppb is 1,2-(Ph(2)P)(2)C(6)H(4). The more stable geometric isomer of MeReO(mtp)X forms MeReO(mtp)Y (X, Y = PR(3), NC(5)H(4)R) in two steps, both of which(More)
Chelating dithiolate ligands--e.g., mtp from 2-(mercaptomethyl)thiophenol, edt from 1,2-ethanedithiol, and pdt from 1,3-propanedithiol--stabilize high-valent oxorhenium(V) against hydrolytic and oxidative decomposition. In addition to the dithiolate chelating to a single rhenium, one sulfur forms a coordinate bond to the other rhenium. In one arrangement(More)