David V Doyle

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Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women : The Chingford Study

Deborah J. Hart, David V Doyle, Tim D. Spector
Arthritis and rheumatism
1999

OBJECTIVE To examine the natural history, role of risk factors, and incidence of knee osteoarthritis (OA) in a prospective study of women from a population cohort. METHODS Women from the Chingford… (More)

The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study.

Deborah J. Hart, Indeera Mootoosamy, David V Doyle, Tim D. Spector
Annals of the rheumatic diseases
1994

OBJECTIVE A total of 979 women from the Chingford general population survey were studied to examine the hypothesis that osteoarthritis (OA) and osteoporosis are inversely related. METHODS All women… (More)

Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease.

Tim D. Spector, Deborah J. Hart, +4 authors Mark B Pepys
Arthritis and rheumatism
1997

OBJECTIVE To examine the role of low-grade inflammation in the etiology and progression of early osteoarthritis (OA) of the knee. METHODS We used a new, high-sensitivity, automated monoclonal… (More)

The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee: the Chingford Study.

Deborah J. Hart, Camille Cronin, M. V. Daniels, Tina Worthy, David V Doyle, Tim D. Spector
Arthritis and rheumatism
2002

OBJECTIVE Investigators performing cross-sectional studies have reported small increases in bone mineral density (BMD) in subjects with osteoarthritis (OA). This study was undertaken to examine the… (More)

Effect of hormone replacement therapy on bone mass in rheumatoid arthritis patients treated with and without steroids.

George M. Hall, M. V. Daniels, David V Doyle, Tim D. Spector
Arthritis and rheumatism
1994

OBJECTIVE To assess the effect of hormone replacement therapy (HRT) on bone mass in rheumatoid arthritis (RA) patients treated with and those not treated with steroids. METHODS Two hundred… (More)

The links between joint damage and disability in rheumatoid arthritis.

David Lloyd Scott, Klaus Pugner, +4 authors Klaus Hieke
Rheumatology
2000

OBJECTIVE The characteristic joint damage and disability of rheumatoid arthritis (RA) increase slowly over 10-20 yr. Although it is generally believed that persisting inflammatory synovitis causes… (More)

Association between metabolic factors and knee osteoarthritis in women: the Chingford Study.

Deborah J. Hart, David V Doyle, Tim D. Spector
The Journal of rheumatology
1995

OBJECTIVE Several studies have shown an association with density and knee osteoarthritis (OA), however the role of other metabolic factors is unclear, with conflicting data in the literature. We… (More)

Association study of candidate genes for the prevalence and progression of knee osteoarthritis.

Ana M Valdes, Deborah J. Hart, +5 authors Tim D. Spector
Arthritis and rheumatism
2004

OBJECTIVE Osteoarthritis (OA), characterized by late-onset degeneration of articular cartilage, is recognized to have a genetic component. We examined the role of 26 single-nucleotide polymorphisms… (More)

Fear of falling limiting activity in young-old women is associated with reduced functional mobility rather than psychological factors.

Finbarr C. Martin, Deborah J. Hart, Tim D. Spector, David V Doyle, Danielle Harari
Age and ageing
2005

BACKGROUND many older people experience fear of falling. This is sometimes associated with activity limitation, with potential adverse health implications. The explanatory contributions of physical… (More)

Touch-screen computer systems in the rheumatology clinic offer a reliable and user-friendly means of collecting quality-of-life and outcome data from patients with rheumatoid arthritis.

M. C. Greenwood, Alan J. Hakim, Ewart Carson, David V Doyle
Rheumatology
2006

OBJECTIVES To investigate the feasibility of collecting rheumatoid arthritis (RA) patient self-administered outcome data using touch-screen computers in a routine out-patient clinic. METHODS Forty… (More)

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