The Structured Interview of Malingered Symptomatology (SIMS) is a self-report instrument that asks patients whether they experience atypical or implausible symptoms. The instrument has not been evaluated in an epilepsy population, and the potential for it to accurately distinguish between patients with psychogenic non-epileptic events (PNEE) and epileptic… (More)
The design and performance evaluation of an entry guidance algorithm for future space transportation vehicles is presented. The guidance concept is to plan and track aerodynamic acceleration. This concept, on which the longitudinal entry guidance for the Space Shuttle Orbiter is based, is extended to integrated longitudinal and lateral guidance. With… (More)
This paper presents the design and performance of Evolved Acceleration Guidance Logic for Entry (EAGLE), an algorithm intended for future space transportation vehicles. The most distinguishing feature of EAGLE is its ability to plan a three-dimensional trajectory and thereby handle large crossrange entries. EAGLE consists of two integrated components: a… (More)
Meta-analyses of bipolar disorder (BD) genome-wide association studies (GWAS) have identified several genome-wide significant signals in European-ancestry samples, but so far account for little of the inherited risk. We performed a meta-analysis of ∼750,000 high-quality genetic markers on a combined sample of ∼14,000 subjects of European and Asian-ancestry… (More)
Use of novel drug delivery methods might enhance efficacy and reduce toxicity, in comparison with currently existing oral anti-epileptic drugs (AEDs). Novel methods aim to deliver optimal drug concentration more specifically to the seizure focus or foci. In this review, we first consider unconventional routes of drug delivery to the peripheral system, then… (More)
since 1951, it is now a weekly with 48 issues per year.
BACKGROUND Retinal cell development has been extensively investigated; however, the current knowledge of dynamic morphological and molecular changes is not yet complete. RESULTS This study was aimed at revealing the dynamic morphological and molecular changes in retinal cell development during the embryonic stages using a new method of targeted retinal… (More)
OBJECTIVE This cross-sectional mortality linkage study describes the prevalence of specific fatal disease and injury conditions in an adult population with serious mental illness. The large sample of decedents and the use of multiple-cause-of-death data yield new clinical details relevant to those caring for persons with serious mental illness. METHODS… (More)