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Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in amyotrophic lateral sclerosis (ALS) and a subgroup of frontotemporal lobar degeneration (FTLD-TDP). Identification of mutations in the gene encoding TDP-43 (TARDBP) in familial ALS confirms a mechanistic link between misaccumulation of TDP-43 and neurodegeneration and(More)
Glial proliferation and activation are associated with disease progression in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia. In this study, we describe a unique platform to address the question of cell autonomy in transactive response DNA-binding protein (TDP-43) proteinopathies. We generated functional astroglia from human induced(More)
The glial environment is an important determinant of neuronal health in experimental models of neurodegeneration. Specifically, astrocytes have been shown, dependent on context, to be both injurious and protective. Human pluripotent stem cells offer a powerful new system to improve our understanding of the mechanisms underlying astrocyte-mediated(More)
Hypothermia is potently neuroprotective, but the molecular basis of this effect remains obscure. Changes in neuronal tau protein are of interest, since tau becomes hyperphosphorylated in injury-resistant, hypothermic brains. Noting inter-species differences in tau isoforms, we have used functional cortical neurons differentiated from human pluripotent stem(More)
Rodent-based studies have shown that the membrane properties of oligodendrocytes play prominent roles in their physiology and shift markedly during their maturation from the oligodendrocyte precursor cell (OPC) stage. However, the conservation of these properties and maturation processes in human oligodendrocytes remains unknown, despite their dysfunction(More)
An autonomous computer vision-guided plant sensing and monitoring system was designed and constructed to continuously monitor temporal, morphological, and spectral features of lettuce crop growing in a nutrient film technique (NFT) hydroponics system. The system consisted of five main components including (1) a stepper motor-driven camera positioning(More)
Isolated rat livers were perfused under controlled conditions with two hepatocarcinogens, aflatoxin B, (AFB,) and Sterig matocystin. Both were metabolically activated to molecular forms that bound to DMA yielding carcinogen-DNA component adducts that were released by acidic hydrolysis and analyzed by high-pressure liquid chromatography. Binding to DMA was(More)
OBJECTIVE To examine the environmental life cycle from poppy farming through to production of 100 mg in 100 mL of intravenous morphine (standard infusion bag). DESIGN 'Cradle-to-grave' process-based life cycle assessment (observational). SETTINGS Australian opium poppy farms, and facilities for pelletising, manufacturing morphine, and sterilising and(More)
This talk aims to discuss risk factors for perioperative mortality with particular emphasis on preoperative patient factors and postoperative complications. In 2010 we published a study of perioperative mortality and complications in Anaesthesia. 1 We called this study the REASON study; a slightly dodgy acronym: Research into Elderly Patient Anaesthesia and(More)
As members of the Dissertation Committee, we certify that we have read the dissertation prepared by David Lee Story, Jr. titled " Autonomous multi-sensor and web-based decision support for crop diagnostics in greenhouse " and recommend that it be accepted as fulfilling the dissertation requirement for the Degree of Doctor of Philosophy. Final approval and(More)