2Markus Diesing
1Carlo Nike Bianchi
1Ralph Diclemente
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We have recently shown that injection of the hypothalamic peptide cocaine and amphetamine regulated transcript (CART) into discrete hypothalamic nuclei stimulates food intake. This stimulation was particularly marked in the arcuate nucleus. Here we show that twice daily intra-arcuate injection of 0.2 nmole CART peptide for 7 days was associated with a 60%(More)
22 Nuclear Magnetic Resonance (NMR) spectra are widely used in metabolomics to 23 obtain profiles of metabolites dissolved in biofluids such as cell supernatants. Methods 24 for estimating metabolite concentrations from these spectra are presently confined to 25 manual peak fitting and to binning procedures for integrating resonance peaks. Exten-26 sive(More)
Detailed seabed substrate maps are increasingly in demand for effective planning and management of marine ecosystems and resources. It has become common to use remotely sensed multibeam echosounder data in the form of bathymetry and acoustic backscatter in conjunction with ground-truth sampling data to inform the mapping of seabed substrates. Whilst, until(More)
Noscapine, a plant-derived, non-toxic, over-the-counter antitussive alkaloid has tubulin-binding properties. Based upon the structural resemblance of noscapine to colchicine, a tubulin-binding anti-inflammatory drug, noscapine and its semi-synthetic brominated analogs were examined for in vitro anti-inflammatory activity. Brominated noscapine analogs were(More)
Health care workers (HCWs) in high TB burden countries bear significant risks of being infected with Mycobacterium tuberculosis and developing TB disease through their work. In recent years, an increasing number of people living with HIV (PLHIV) are taking part in delivering HIV and other health services in resource-limited settings with high TB burden. The(More)
Gender differences in the discriminative stimulus properties of drugs of abuse have sometimes been reported, although we have previously found no differences in subjective or discriminative responses in human subjects acquiring an alcohol discrimination. The aim of the present work was to determine if there were gender differences in the effects of(More)
There is a need for fit-for-purpose maps for accurately depicting the types of seabed substrate and habitat and the properties of the seabed for the benefits of research, resource management, conservation and spatial planning. The aim of this study is to determine whether it is possible to predict substrate composition across a large area of seabed using(More)
For the movie "2012", Digital Domain was tasked with destroying its home city of Los Angeles... digitally. The destruction effects would be seen up close, and there had to be a lot of it. The solution involved turning to geometric fracturing tools, and rigid body dynamics (RBD) simulations. However, this sequence was going to require two orders of magnitude(More)
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