David Sparling

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Two-component regulatory systems that utilize a multistep phosphorelay mechanism often involve a histidine-containing phosphotransfer (HPt) domain. These HPt domains serve an essential role as histidine-phosphorylated protein intermediates during phosphoryl transfer from one response regulator domain to another. In Saccharomyces cerevisiae, the YPD1 protein(More)
Overexpression of GLUT4 exclusively in skeletal muscle enhances insulin action and improves glucose homeostasis. Transgenic studies have discovered two regions on the GLUT4 promoter conserved across several species that are required for normal GLUT4 expression in skeletal muscle. These regions contain binding motifs for the myocyte enhancer factor 2 (MEF2)(More)
INTRODUCTION Cooperative business relationships are dramatically changing the structure of the North American agrifood sector. An examination of recent events in the grain industry reveals the extent to which cooperative ventures are becoming integrated into international agribusiness. When Cargill decided to expand its presence in Canada it participated in(More)
INTRODUCTION Globalization is changing the nature and structure of agricultural and food markets. In agriculture, globalization is providing producers with new market opportunities, as well as broader options for sourcing raw material and intermediate inputs. The globalization of the food industries is providing consumers with unprecedented choice and(More)
Mechanistic target of rapamycin complex 1 (mTORC1), defined by the presence of Raptor, is an evolutionarily conserved and nutrient-sensitive regulator of cellular growth and other metabolic processes. To date, all known functions of Raptor involve its scaffolding mTOR kinase with substrate. Here we report that mTORC1-independent ('free') Raptor negatively(More)
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OBJECTIVE As the obesity pandemic continues to expand, novel molecular targets to reduce obesity-related insulin resistance and Type 2 Diabetes (T2D) continue to be needed. We have recently shown that obesity is associated with reactivated liver Notch signaling, which, in turn, increases hepatic insulin resistance, opening up therapeutic avenues for Notch(More)
This article uses the case method of research to analyze the strategies and strengths of independent, domestically owned, successful medium-sized processing companies in Canada+ The assessment of company strengths is based on responses from open-ended interviews and a questionnaire+ All assessment is based on managers' perceptions, and the theoretical(More)
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