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BACKGROUND Seizure prediction would be clinically useful in patients with epilepsy and could improve safety, increase independence, and allow acute treatment. We did a multicentre clinical feasibility study to assess the safety and efficacy of a long-term implanted seizure advisory system designed to predict seizure likelihood and quantify seizures in(More)
Recently, deep neural networks (DNN) have been incorporated into i-vector-based speaker recognition systems, where they have significantly improved state-of-the-art performance. In these systems, a DNN is used to collect sufficient statistics for i-vector extraction. In this study, the DNN is a recently developed time delay deep neural network (TDNN) that(More)
BACKGROUND Inhalation of airborne particulate matter (PM) derived from urban traffic is associated with pathology in the arteries, heart, and lung; effects on brain are also indicated but are less documented. OBJECTIVE We evaluated rodent brain responses to urban nanoscale (< 200 nm) PM (nPM). METHODS Ambient nPM collected near an urban freeway was(More)
Temozolomide (TMZ) is an alkylating agent shown to prolong survival in patients with high grade glioma and is routinely used to treat melanoma brain metastases. A prominent side effect of TMZ is induction of profound lymphopenia, which some suggest may be incompatible with immunotherapy. Conversely, it has been proposed that recovery from(More)
A tool is described that provides for the automatic configuration of systems from a single description. The tool, newfig, uses two simple concepts to provide its functionality: boolean logic for making decisions and file construction for generating the files. Newfig relies heavily on external scripts for anything beyond the construction of files. This(More)
Adoptive cellular therapy (ACT) after lymphodepletive conditioning can induce dramatic clinical responses, but this approach has been largely limited to melanoma due to a lack of reliable methods for expanding tumor-specific lymphocytes from the majority of other solid cancers. We have employed tumor RNA-pulsed dendritic cells (DCs) to reliably expand CD4 C(More)
When we last reported the status of the U.C. Berkeley Infrared Spatial Interferometer (ISI) in 2002, 1 we p r e-sented simulations, based upon our two-telescope experience, for the expected performance of a three-telescope array t h a t w ould be capable of measuring three simultaneous visibilities and one closure phase at mid-infrared wavelengths. The ISI(More)
INTRODUCTION Adoptive transfer of T cells expressing chimeric antigen receptors (CARs) is an effective immunotherapy for hematological cancers but requires a rethinking for clinical efficacy against solid tumors, where CARs have largely failed. Lymphodepletive preconditioning regimens can enhance CAR activity in vivo by promoting T-cell expansion and(More)