David Sigfredo Angulo

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In this paper, we introduced a framework for experiment management that simplifies the users' interaction with grid environments by managing a large number of tasks to be conducted as part of the experiment by the individual scientist. Our framework is an extension to the Java CoG Kit. We have developed a client-server approach that allows us to utilize the(More)
A significant consequence of protein phosphorylation is to alter protein-protein interactions, leading to dynamic regulation of the components of protein complexes that direct many core biological processes. Recent proteomic studies have populated databases with extensive compilations of cellular phosphoproteins and phosphorylation sites and a similarly(More)
Acknowledgments The Government retains for itself, and others acting on its behalf, a paid-up, nonexclusive, irrevocable worldwide license in said article to reproduce, prepare derivative works, distribute copies to the public, and perform publicly and display publicly, by or on behalf of the Government. 2 Introduction Cluster & Batch Queuing System: enable(More)
Proteomic researchers who study mass spectrometry data have expressed a need for an accurate public database of empirically derived curated mass spectrum information. Lack of such a database limits proteomic researchers in their ability to identify and study proteins. Until recently, storage space and computing power has been the limiting factor in(More)
The manipulation of codon selection in synthetic genes greatly influences expression of the gene's products i.e. proteins. Biologists frequently have multiple objectives when constructing a synthetic gene for a given protein sequence and are often limited by the tools and mechanisms used to design genes in vitro. Poor codon choice and mRNA secondary(More)
Mass spectrometry (MS) is technology used to study gas-phase ions by mass analysis, i.e., the separation of ions by their m/z (mass/charge) values. Although various mass spectrometers differ in their sensitivity and technology used in calculating m/z, all of them generate mass spectra as output. MS technology has become a central tool in the study of(More)
Database searching for protein identification is an efficient approach for MS/MS spectra identification compared to the existing approaches, such as protein identification with antibodies, and chemical degradation. In order for a database search to give reliable results, the database itself, as well as the searching algorithm, must be reliable. However,(More)
Mass spectrometry (MS) is an analytical method biologists and chemists use to sequence and identify unknown proteins. Although sensitivity and sample analysis modalities differ, mass spectrometers basically consist of an ion source, a mass analyzer, and a detector. The final output is a single mass spectrum or a series of mass spectra depending on the(More)