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The false discovery rate (FDR) is a multiple hypothesis testing quantity that describes the expected proportion of false positive results among all rejected null hypotheses. Benjamini and Hochbergâ€¦ (More)

- David Siegmund
- SIAM Review
- 1990

- JosÃ©e Dupuis, David Siegmund
- Genetics
- 1999

Lander and Botstein introduced statistical methods for searching an entire genome for quantitative trait loci (QTL) in experimental organisms, with emphasis on a backcross design and QTL having onlyâ€¦ (More)

- Yao Xie, David Siegmund
- 2013 Information Theory and Applications Workshopâ€¦
- 2013

We develop a mixture procedure to monitor parallel streams of data for a change-point that affects only a subset of them, without assuming a spatial structure relating the data streams to oneâ€¦ (More)

- Hua Tang, David Siegmund
- Biostatistics
- 2001

We discuss strategies for mapping quantitative trait loci with emphasis on certain issues of study design that have recently received attention: e.g. genotyping only selected pedigrees and theâ€¦ (More)

- John D. Storey, David Siegmund
- Journal of Computational Biology
- 2001

Siegmund and Yakir (2000) have given an approximate p-value when two independent, identically distributed sequences from a finite alphabet are optimally aligned based on a scoring system that rewardsâ€¦ (More)

Two new derivations of the Hotelling-Naiman results on volume of tubes about curves in spheres are presented. The first involves simple differential inequalities. The second is probabilistic, usingâ€¦ (More)

- JoseÃ© Dupuis, Patrick O. Brown, David Siegmund
- Genetics
- 1995

A multilocus model for complex traits is described that generalizes the additive and multiplicative models and hence allows simultaneously for both heterogeneity and gene interaction (epistasis).â€¦ (More)

- Sally C. Morton, Kirk Cameron, +10 authors David Siegmund
- 1989

The goal of this thesis is to modify projection pursuit by trading accuracy for interpretability. The modification produces a more parsimonious and understandable model without sacrificing theâ€¦ (More)

- T L Lai, Beth Levin, Herbert Robbins, David Siegmund
- Proceedings of the National Academy of Sciencesâ€¦
- 1980

A model for sequential clinical trials is discussed. Three proposed stopping rules are studied by the Monte Carlo method for small patient horizons and mathematically for large patient horizons. Theyâ€¦ (More)