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Chapter Overview This chapter discusses analytic and algorithmic results for computational protein structure prediction by protein sequence-structure alignment, an approach also known as protein threading. Biological results are beyond the scope of this chapter, but may be found in 1, 2 , 3 , 4. See also the chapter by D a vid Jones in this volume, which(More)
OBJECTIVE To develop a grading scale to predict the risk of intracerebral hemorrhage (ICH) and prognosis after treatment with IV tissue-plasminogen activator (t-PA) in patients with ischemic stroke. METHODS We constructed a five-point scale based on NIH Stroke Scale score, extent of hypodensity on CT scan, serum glucose at baseline, and history of(More)
OBJECTIVE To identify patterns of clinical presentation, imaging findings, and etiologies in a cohort of hospitalized patients with localized nontraumatic convexal subarachnoid hemorrhage. METHODS Twenty-nine consecutive patients with atraumatic convexal subarachnoid hemorrhage were identified using International Classification of Diseases-9 code from 460(More)
OBJECTIVE To evaluate the frequencies of symptoms and signs in patients with posterior circulation ischemia in a large case series of prospectively collected patients. DESIGN Case series. SETTING Outpatient and inpatient setting at the New England Medical Center, a tertiary care referral center in Boston, Massachusetts. PATIENTS Consecutive sample of(More)
Since its original description in 2007, anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis associated with an ovarian teratoma is an increasingly recognized etiology of previously unexplained encephalopathy and encephalitis. Extreme delta brush (EDB) is a novel electroencephalogram (EEG) finding seen in many patients with anti-NMDAR encephalitis.(More)
BACKGROUND The ABCD(2) score is increasingly being used to triage patients with transient ischemic attack (TIA). Whether the score can predict the need for in-hospital intervention (IHI), other than initiation of antiplatelets and statins, is unknown. AIMS The ability of the ABCD(2) score to predict IHI would strengthen the rationale to use it as a(More)
This study investigated the influence of age, National Institutes of Health Stroke Scale (NIHSS) score, time from stroke onset, infarct location and volume in predicting placement of a percutaneous endoscopic gastrostomy (PEG) tube in patients with severe dysphagia from an acute-subacute hemispheric infarction. We performed a retrospective analysis of a(More)