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Advances in techniques for recording large-scale brain activity contribute to both the elucidation of neurophysiological principles and the development of brain-machine interfaces (BMIs). Here we describe a neurophysiological paradigm for performing tethered and wireless large-scale recordings based on movable volumetric three-dimensional (3D)(More)
Neuroprosthetic devices based on brain-machine interface technology hold promise for the restoration of body mobility in patients suffering from devastating motor deficits caused by brain injury, neurologic diseases and limb loss. During the last decade, considerable progress has been achieved in this multidisciplinary research, mainly in the brain-machine(More)
Several groups have developed brain-machine-interfaces (BMIs) that allow primates to use cortical activity to control artificial limbs. Yet, it remains unknown whether cortical ensembles could represent the kinematics of whole-body navigation and be used to operate a BMI that moves a wheelchair continuously in space. Here we show that rhesus monkeys can(More)
Protein folding refers to the process whereby a protein assumes its intricate three-dimensional shape. This chapter reviews a class of methods for studying the folding process called roadmap methods. The goal of these methods is not to predict the folded structure of a protein, but rather to analyze the folding kinetics. It is assumed that the folded state(More)
The activity of most drugs is regulated by the binding of one molecule (the lig-and) to a pocket of another, usually larger, molecule, which is commonly a protein. This report describes a new approach to creating low-energy structures of flexible proteins to which ligands can be docked. The flexibility of molecules is encoded with thousands of parameters(More)
Personal robots will contribute mobile manipulation capabilities to our future smart homes. In this paper, we propose a low-cost object localization system that uses static devices with Bluetooth capabilities , which are distributed in an environment, to detect and localize active Bluetooth beacons and mobile devices. This system can be used by a robot to(More)
OBJECTIVE To describe a method of cochlear implantation in which the opening of the cochlea and the electrode array insertion are performed under water (underwater technique). STUDY DESIGN Retrospective patient review. SETTING Academic tertiary referral center. PATIENTS Fifteen implantations in children and adult patients with residual hearing at the(More)
HYPOTHESIS The acoustic properties of scaffolds made from decellularized extracellular cartilage matrices of porcine origin are comparable to those of the human tympanic membrane. BACKGROUND Currently, the reconstruction of tympanic membrane in the context of chronic tympanic membrane defects is mostly performed using autologous fascia or cartilage.(More)
HYPOTHESIS High loads forcing the floating mass transducer (FMT) of a single active middle ear implant toward the round window membrane (RWM) affect the backward stimulation of the cochlea. BACKGROUND Various factors influence the backward stimulation of the cochlea. We investigated the effects of various loads applied to the FMT together with different(More)
OBJECTIVE Analysis of the audiometric results after repair of a defective footplate with the sandwich cartilage shoe technique in a follow-up study. STUDY DESIGN Retrospective analysis of audiometric data. SETTING Hospital. PATIENTS The cohort consisted of 12 patients, who underwent ossicular reconstruction after sandwich cartilage shoe technique in a(More)