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Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

• David S. Bredt, Solomon H Snyder
• Proceedings of the National Academy of Sciences…
• 1990

Nitric oxide mediates vascular relaxing effects of endothelial cells, cytotoxic actions of macrophages and neutrophils, and influences of excitatory amino acids on cerebellar cyclic GMP. Its… (More)

Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

• Lu Chen, Dane M. Chetkovich, +5 authors Roger A Nicoll
• Nature
• 2000

Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate) receptors on cerebellar granule cells. Stargazin, the mutated protein,… (More)

AMPA Receptor Trafficking at Excitatory Synapses

• David S. Bredt, Roger A Nicoll
• Neuron
• 2003

Excitatory synapses in the CNS release glutamate, which acts primarily on two sides of ionotropic receptors: AMPA receptors and NMDA receptors. AMPA receptors mediate the postsynaptic depolarization… (More)

Nitric oxide in skeletal muscle

• Lester Kobzik, Michael B. Reid, David S. Bredt, Jonathan S. Stamler
• Nature
• 1994

REACTIVE oxygen intermediates modulate skeletal muscle contraction1,2, but little is known about the role of nitric oxide (NO). Here we show that rat skeletal muscle expresses neuronal-type NO… (More)

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

• Jay E. Brenman, Daniel S Chao, +9 authors David S. Bredt
• Cell
• 1996

Neuronal nitric oxide synthase (nNOS) is concentrated at synaptic junctions in brain and motor endplates in skeletal muscle. Here, we show that the N-terminus of nNOS, which contains a PDZ protein… (More)

PSD-95 involvement in maturation of excitatory synapses.

• Alaa El-Din El-Husseini, Eric Schnell, Dane M. Chetkovich, Roger A Nicoll, David S. Bredt
• Science
• 2000

PSD-95 is a neuronal PDZ protein that associates with receptors and cytoskeletal elements at synapses, but whose function is uncertain. We found that overexpression of PSD-95 in hippocampal neurons… (More)

Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins

• Susumu Tomita, Lu Chen, +4 authors David S. Bredt
• The Journal of cell biology
• 2003

Functional expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in cerebellar granule cells requires stargazin, a member of a large family of four-pass… (More)

Nitric oxide, a novel neuronal messenger

• David S. Bredt, Solomon H Snyder
• Neuron
• 1992

Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number.

• Eric Schnell, Max Sizemore, Siavash Karimzadegan, Lu Chen, David S. Bredt, Roger A Nicoll
• Proceedings of the National Academy of Sciences…
• 2002

Excitatory synapses in the brain exhibit a remarkable degree of functional plasticity, which largely reflects changes in the number of synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic… (More)

Stargazin modulates AMPA receptor gating and trafficking by distinct domains

• Susumu Tomita, Hillel Adesnik, +5 authors David S. Bredt
• Nature
• 2005

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors mediate fast excitatory synaptic transmission in the brain. These ion channels rapidly deactivate and desensitize, which… (More)

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