David S. Silber

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Virilization in women is associated with increased production of testosterone as well as a variety of androgenic prehormones, including androstenedione, androstenediol, DHEA, DHEA-sulfate, dihydrotestosterone and androstanediol. Of these hormones, it is likely that testosterone is the androgen which initiates a series of androgen-receptor mediated events(More)
Blood production rates of testosterone, dihydrotestosterone (DHT), and 3 alpha-androstanediol (3 alpha-diol) were found to be approximately 2-fold elevated in morbidly obese, nonhirsute, normally menstruating women. Values were intermediate between those found in normal women and those in a group of nonobese normally menstruating women with idiopathic(More)
The site of androgen synthesis was determined in 21 women with polycystic ovary syndrome on the basis of radiographic studies, catheterization of ovarian and adrenal veins, and/or inferior vena cava samplings. Gradients of testosterone, androstenedione, and dehydroepiandrosterone sulfate were determined by comparing the levels in adrenal and ovarian veins(More)
The biosynthesis of aldolase A and B subunits has been studied in rat liver during the administration of carcinogen AAF4. Transition from a predominance of aldolase B to A was observed during carcinogenesis in rat liver. Changes in isozymic pattern and FDP to F-1-P cleavage activity ratio were observed before histological alterations typical of hepatoma(More)
Bendamustine, a bifunctional alkylating agent, is currently in clinical trials for the treatment of hematological and other malignan-cies. Although it has been used in the former East Germany for more than 30 years, very limited information is available on its biotransformation. The objective of this investigation was to obtain information on the structures(More)