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A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes
Drosophila melanogaster, like other invertebrates, relies solely on its innate immune response to fight invading microbes; by definition, innate immunity lacks adaptive characteristics. However, weExpand
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Disease Tolerance as a Defense Strategy
Enduring Tolerance During an infection, the host organism deploys multiple defense strategies. Disease resistance, the process by which the immune system decreases pathogen burden is perhaps the mostExpand
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Tolerance of infections.
A host has two methods to defend against pathogens: It can clear the pathogens or reduce their impact on health in other ways. The first, resistance, is well studied. Study of the second, whichExpand
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The Imd Pathway Is Involved in Antiviral Immune Responses in Drosophila
Cricket Paralysis virus (CrPV) is a member of the Dicistroviridae family of RNA viruses, which infect a broad range of insect hosts, including the fruit fly Drosophila melanogaster. Drosophila hasExpand
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Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases
A host can evolve two types of defence mechanism to increase its fitness when challenged with a pathogen: resistance and tolerance. Immunology is a well-defined field in which the mechanisms behindExpand
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Akt and foxo Dysregulation Contribute to Infection-Induced Wasting in Drosophila
BACKGROUND Studies in Drosophila have taught us a great deal about how animals regulate the immediate innate immune response, but we still know little about how infections cause pathology. Here, weExpand
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A Signaling Protease Required for Melanization in Drosophila Affects Resistance and Tolerance of Infections
Organisms evolve two routes to surviving infections—they can resist pathogen growth (resistance) and they can endure the pathogenesis of infection (tolerance). The sum of these two propertiesExpand
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Reciprocal Analysis of Francisella novicida Infections of a Drosophila melanogaster Model Reveal Host-Pathogen Conflicts Mediated by Reactive Oxygen and imd-Regulated Innate Immune Response
The survival of a bacterial pathogen within a host depends upon its ability to outmaneuver the host immune response. Thus, mutant pathogens provide a useful tool for dissecting host-pathogenExpand
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Exploration of host–pathogen interactions using Listeria monocytogenes and Drosophila melanogaster
Summary The facultative intracellular bacterial pathogen Listeria monocytogenes is capable of replicating within a broad range of host cell types and host species. We report here the establishment ofExpand
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WntD is a feedback inhibitor of Dorsal/NF-κB in Drosophila development and immunity
Regulating the nuclear factor-κB (NF-κB) family of transcription factors is of critical importance to animals, with consequences of misregulation that include cancer, chronic inflammatory diseasesExpand
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