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  • David S Perlin
  • Biology, Medicine
  • Drug resistance updates : reviews and…
  • 2007 (First Publication: 1 June 2007)
  • Invasive fungal infections cause morbidity and mortality in severely ill patients, and limited drug classes restrict treatment choices. The echinocandin drugs are the first new class of antifungalExpand
  • Steven Y. Park, Rosemarie Kelly, +15 authors David S Perlin
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 2005 (First Publication: 1 August 2005)
  • ABSTRACT An association between reduced susceptibility to echinocandins and changes in the 1,3-β-d-glucan synthase (GS) subunit Fks1p was investigated. Specific mutations in fks1 genes fromExpand
  • Barbara D. Alexander, Melissa D. Johnson, +7 authors Michael A. Pfaller
  • Medicine
  • Clinical infectious diseases : an official…
  • 2013 (First Publication: 15 June 2013)
  • BACKGROUND Fluconazole (FLC) resistance is common in C. glabrata and echinocandins are often used as first-line therapy. Resistance to echinocandin therapy has been associated with FKS1 and FKS2 geneExpand
  • Michael A. Pfaller, Daniel J. Diekema, +5 authors David S Perlin
  • Biology, Medicine
  • Drug resistance updates : reviews and…
  • 2011 (First Publication: 1 June 2011)
  • The CLSI established clinical breakpoints (CBPs) for caspofungin (CSF), micafungin (MCF) and anidulafungin (ANF) versus Candida. The same CBP (susceptible (S): MIC ≤ 2 mcg/ml; non-S: MIC > 2 mcg/ml)Expand
  • Guillermo García-Effrón, Santosh K Katiyar, Steven Y. Park, Thomas D. Edlind, David S Perlin
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 2008 (First Publication: 28 April 2008)
  • ABSTRACT Candida parapsilosis has emerged as a common cause of invasive fungal infection, especially in Latin America and in the neonatal setting. C. parapsilosis is part of a closely related groupExpand
  • Guillermo García-Effrón, Steven Park, David S Perlin
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 2008 (First Publication: 27 October 2008)
  • ABSTRACT A detailed kinetic characterization of echinocandin inhibition was performed for mutant 1,3-β-d-glucan synthase enzymes from clinical isolates of Candida albicans with nine different FKS1Expand
  • Sergey V. Balashov, Steven Y. Park, David S Perlin
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 2006 (First Publication: 1 June 2006)
  • ABSTRACT Resistance of clinical isolates of Candida albicans to the echinocandin drug caspofungin is slowly emerging and is linked to mutations in short conserved regions in the FKS1 gene. The mostExpand
  • Adriana Mendes do Nascimento, Gustavo Henrique Goldman, +7 authors David S Perlin
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 2003 (First Publication: 1 May 2003)
  • ABSTRACT A collection of Aspergillus fumigatus mutants highly resistant to itraconazole (RIT) at 100 μg ml−1 were selected in vitro (following UV irradiation as a preliminary step) to investigateExpand
  • David W. Denning, Steven Y. Park, +8 authors David S Perlin
  • Medicine
  • Clinical infectious diseases : an official…
  • 2011 (First Publication: 1 May 2011)
  • BACKGROUND Oral triazole therapy is well established for the treatment of invasive (IPA), allergic (ABPA), and chronic pulmonary (CPA) aspergillosis, and is often long-term. Triazole resistance ratesExpand