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Electroporation is a physical method to induce the uptake of therapeutic drugs and DNA, by eukaryotic cells and tissues. The phenomena behind electro-mediated membrane permeabilization to plasmid DNA have been shown to be significantly more complex than those for small molecules. Small molecules cross the permeabilized membrane by diffusion whereas plasmid(More)
We study a fragmentation problem where an initial object of size x is broken into m random pieces provided x > x0 where x0 is an atomic cutoff. Subsequently the fragmentation process continues for each of those daughter pieces whose sizes are bigger than x0. The process stops when all the fragments have sizes smaller than x0. We show that the fluctuation of(More)
We study the effect of permeabilizing electric fields applied to two different types of giant unilamellar vesicles, the first formed from EggPC lipids and the second formed from DOPC lipids. Experiments on vesicles of both lipid types show a decrease in vesicle radius, which is interpreted as being due to lipid loss during the permeabilization process. We(More)
We consider a tapping dynamics, analogous to that in experiments on granular media, on spin glasses and ferromagnets on random thin graphs. Between taps, zero temperature single spin flip dynamics takes the system to a metastable state. Tapping corresponds to flipping simultaneously any spin with probability p. This dynamics leads to a stationary regime(More)
Insights into the mechanisms of electromediated gene delivery and application to the loading of giant vesicles with negatively charged macromolecules † We present experimental results regarding the electrotransfer of plasmid DNA into phosphatidylcholine giant unilamellar vesicles (GUVs). Our observations indicate that a direct entry is the predominant(More)
Modern developments in microscopy and image processing are revolutionizing areas of physics, chemistry, and biology as nanoscale objects can be tracked with unprecedented accuracy. The goal of single-particle tracking is to determine the interaction between the particle and its environment. The price paid for having a direct visualization of a single(More)
Motivated by a computer science algorithm known as "linear probing with hashing," we study a new type of percolation model whose basic features include a sequential "dropping" of particles on a substrate followed by their transport via a "pushing" mechanism. Our exact solution in one dimension shows that, unlike the ordinary random percolation model, the(More)
We study the random m-ary search tree model (where m stands for the number of branches of a search tree), an important problem for data storage in computer science, using a variety of statistical physics techniques that allow us to obtain exact asymptotic results. In particular, we show that the probability distributions of extreme observables associated(More)