David Rott

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OBJECTIVE Previous studies suggest that heat shock protein (HSP) 60 has a contributory role in atherosclerosis development. We examined whether circulating HSP70 protein and anti-HSP70 antibodies are associated with coronary artery disease (CAD). METHODS AND RESULTS Blood samples from 421 patients (62% men, mean age 57 years) evaluated for CAD by coronary(More)
BACKGROUND Antibodies to mycobacterial heat-shock protein (HSP) 65 have been reported to be associated with carotid artery thickening. We examined whether antibodies to human HSP60 are associated with the risk of coronary artery disease (CAD). METHODS AND RESULTS Blood samples from 391 patients (62% men, mean age 57 years) being evaluated for CAD by(More)
Although both vasopressin and stress have been implicated in the course of schizophrenia, it is unknown whether schizophrenic patients have altered stress-induced function of the vasopressinergic system. We examined the effects of acute metabolic stress induced by pharmacological doses (40 mg/kg) of 2-deoxyglucose (2DG) on plasma concentrations of(More)
BACKGROUND Previous studies demonstrated an association between antibodies to mycobacterial heat-shock protein 65 (mHSP65) and carotid artery thickening. We examined whether mHSP65 antibodies are associated with levels of coronary calcification that appear to reflect preclinical coronary artery disease (CAD). METHODS AND RESULTS Serum specimens from 201(More)
Previous studies have documented discordant cellular and humoral immune responses to subjects exposed to HIV-1, and that the nature of such responses may determine susceptibility and resistance to disease. We determined whether there is a spectrum of cellular versus humoral immunodominant responses to cytomegalovirus (CMV) infection. Blood samples from 50(More)
RATIONALE Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function. OBJECTIVE The aim of this study was to investigate these alterations during a perturbed homeostatic state. METHODS Fifteen patients with schizophrenia and 13 healthy individuals were given a(More)
RATIONALE Several lines of evidence suggest that cocaine expectancy and craving are two related phenomena. The present study assessed this potential link by contrasting reactions to varying degrees of the drug's perceived availability. METHOD Non-treatment seeking individuals with cocaine dependence were administered an intravenous bolus of cocaine (0.2(More)
Giant precordial T wave inversion (GPTI) on ECG may be the result of several pathologies, including myocardial ischemia, pulmonary edema, pulmonary embolism, subarachnoid hemorrhage, apical hypertrophy, and postpacing. We describe a case of a 75-year-old woman who developed GPTI after an episode of gastroenteritis. To our knowledge, this is the first report(More)
In a recent editorial, Dr Christopher P. Cannon reviewed the published studies comparing invasive with conservative treatment strategies in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). 1 He concluded that it has been very clearly shown that an early invasive approach to all patients with NSTE-ACS is beneficial. Dr Cannon didn't mention(More)
AIMS Operative hysteroscopy is associated with complications including the development of gas embolism. The aim of this study was to utilize continuous echocardiographic imaging during operative hysteroscopy to assess the extent and the haemodynamic effects of gas embolism in these patients. METHODS AND RESULTS Women undergoing operative hysteroscopy(More)
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