David Roth

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This paper presents a method of determining the shape of the surface swept by a tool that follows a 5-axis tool path for machining curved surfaces. The method is based on discretizing the tool into pseudo-inserts and identifying imprint points using a modified principle of silhouettes. An imprint point exists for each pseudo-insert, and the piecewise linear(More)
DNA repair by nonhomologous end-joining (NHEJ) relies on the Ku70:Ku80 heterodimer in species ranging from yeast to man. In Saccharomyces cerevisiae and Schizosaccharomyces pombe, Ku also controls telomere functions. Here, we show that Ku70, Ku80, and DNA-PKcs, with which Ku interacts, associate in vivo with telomeric DNA in several human cell types, and we(More)
  • Meredith Fowlie, I Thank, Severin Borenstein, Michael Hanemann, Guido Imbens, Nat Keohane +20 others
  • 2010
When the US federal government first began regulating major sources of air pollution in the 1960s, the conventional approach to meeting air quality standards involved establishing maximum emissions rates or technology based standards for regulated stationary sources. However, economists have long maintained that an emissions permit market could more(More)
BACKGROUND The National Kidney Foundation has formulated clinical practice guidelines for patients with chronic kidney disease (K/DOQI). However, little is know about how many patients actually achieve these goals in a dedicated clinic for chronic kidney disease. METHODS We performed a cross-sectional analysis of 198 patients with an estimated glomerular(More)
Accurate prediction of the swept volume of a cutting tool is essential in NC verification algorithms for detecting deficiencies in a proposed tool path, such as gouging, undercutting and interference. This paper explores a new technique for generating the swept volume of a toroidal endmill, and analyzes the results obtained for two test cases. For a given(More)
OBJECTIVES To catalogue patients with DSD and to assess the concordance of genotype and phenotype with sex assignment at birth compared to sex assignment before and following assessment by a Gender Medicine Team (GMT) at one institution, as an initial step in formulating standardized guidelines for management of these conditions. DESIGN After obtaining(More)
In 2009, an expansion of West Nile virus (WNV) into the Canadian province of British Columbia was detected. Two locally acquired cases of infection in humans and 3 cases of infection in horses were detected by ELISA and plaque-reduction neutralization tests. Ten positive mosquito pools were detected by reverse transcription PCR. Most WNV activity in British(More)
Idiopathic membranous glomerulonephritis (IMGN) is one of the most common causes of nephrotic syndrome in adults. Disease progression is associated with the magnitude and duration of proteinuria [Reichert LJ, Koene RA, Wetzels JF. Prognostic factors in idiopathic membranous nephropathy. Am J Kidney Dis 1998; 31: 1-11]. Membranous nephropathy is also one of(More)