David R. Williamson

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INTRODUCTION The risk of acute kidney injury (AKI) with the use of albumin-containing fluids compared to starches in the surgical intensive care setting remains uncertain. We evaluated the adjusted risk of AKI associated with colloids following cardiac surgery. METHODS We performed a retrospective cohort study of patients undergoing on-pump cardiac(More)
INTRODUCTION Physical restraint (PR) use in the intensive care unit (ICU) has been associated with higher rates of self-extubation and prolonged ICU length of stay. Our objectives were to describe patterns and predictors of PR use. METHODS We conducted a secondary analysis of a prospective observational study of analgosedation, antipsychotic,(More)
BACKGROUND Sedatives and analgesics are administered to provide sedation and manage agitation and pain in most critically ill mechanically ventilated patients. Various sedation administration strategies including protocolized sedation and daily sedation interruption are used to mitigate drug pharmacokinetic limitations and minimize oversedation, thereby(More)
BACKGROUND Traumatic brain injury (TBI) is a worldwide leading cause of mortality and disability. Among TBI complications, agitation is a frequent behavioural problem. Agitation causes potential harm to patients and caregivers, interferes with treatments, leads to unnecessary chemical and physical restraints, increases hospital length of stay, delays(More)
In a retrospective study by a Canadian team [1], pentas-tarch infusion was a dose-related independent risk factor for acute kidney injury (AKI) after cardiac surgery. In a new retrospective cardiac surgery study by that team [2], 83% of patients received hydroxyethyl starch (HES) 130/ 0.4. For unexplained reasons, 25 to 43% of patients received both HES(More)
AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome (ARDS). METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive(More)
Large randomized trials such as the Albumin Italian Outcome Sepsis (ALBIOS) trial involving 1,818 patients with severe sepsis have revealed no evidence of acute kidney injury (AKI) attributable to albumin infusion [1]. Such results are difficult to reconcile with an association between albumin and AKI in the retrospective study by Frenette and colleagues of(More)
In a previous issue of Critical Care, Frenette and colleagues [1] described a retrospective study of 984 cardiac surgery patients receiving mixed colloids, including hydroxyethyl starch (HES) 130/0.4 in 82% or HES 200/ 0.5 in 43%. In 25% or more of the patients, both HES solutions were used. A small minority (16%) received 5% or 25% albumin. An association(More)
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