David R. Renshaw

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Although microfluidics and microarray technologies are revolutionizing the throughput, sensitivity and cost in many areas of biodiagnostics [1], they are still reliant on bulky and expensive fluorescence analysis instrumentation. Conventional fluorescence intensity measurements are prone to misinterpretation due to illumination and fluorophore concentration(More)
A new, simple, and hardware-only fluorescence-lifetime-imaging microscopy (FLIM) is proposed to implement on-chip lifetime extractions, and their signal-to-noise-ratio based on statistics theory is also deduced. The results are compared with Monte Carlo simulations, giving good agreement. Compared with the commonly used iterative least-squares method or the(More)
We describe a two-chip micro-scale time-resolved fluorescence analyzer integrating excitation, detection, and filtering. A new 8×8 array of drivers realized in standard low-voltage 0.35-μm complementary metal-oxide semiconductor is bump-bonded to AlInGaN blue micro-pixellated light-emitting diodes (micro-LEDs). The array is capable of producing sample(More)
We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry and a second device incorporating an 8 × 8 AlInGaN blue micro-pixellated light-emitting diode(More)
We propose the use of dynamic circuits for quenching avalanche events in single photon avalanche diode (SPAD) arrays. Two area-efficient, circuit solutions are presented in 0.35μm CMOS technology. These circuits contain no passive elements and consume shoot-through current only at triggering instants. The resulting reduction in power consumption and supply(More)
A new integration based fluorescence lifetime imaging microscopy (FLIM) called IEM has been proposed to implement lifetime extraction [J. Opt. Soc. Am. A25, 1190 (2008)]. A real-time hardware implementation of the IEM FLIM algorithm suitable for single photon avalanche diode arrays in nanometer-scale CMOS technology is now proposed. The problems of reduced(More)
Light to frequency converters are used to sense the photocurrents of a buried triplejunction pixel achieving high dynamic range and low dark current colour sensing without the use of colour filters. The pixel is realised in a high voltage 0.35μm CMOS enabling sample manipulation by electrowetting and spectral sensing for a FRET biosensor.