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1. Whole-cell patch-clamp recordings were used to investigate possible age-related changes in K+ currents of type 1 carotid body cells isolated from the rat. K+ current density increased with age, as measured in cells isolated from 4-day-old, 10-day-old and adult rats (> or = 5 weeks old). 2. The proportion of current reversibly inhibited by high [Mg2+] (6(More)
1. The effect of PCO2 upon the discharge response to changes in PO2 (between ca 450 and 30 mmHg) was observed in adult (> 5 weeks old) and neonatal (5-7 days old) rat carotid body chemoreceptors using an in vitro, superfused preparation. 2. In both adult and neonatal rats, regression analysis revealed that increasing PCO2 was without effect upon the shape(More)
Ca2+-ATPase of the sarcoplasmic reticulum was localized in cryostat sections from three different adult canine skeletal muscles (gracilis, extensor carpi radialis, and superficial digitalis flexor) by immunofluorescence labeling with monoclonal antibodies to the Ca2+-ATPase. Type I (slow) myofibers were strongly labeled for the Ca2+-ATPase with a monoclonal(More)
The primary goals of this study were to evaluate diurnal patterns of and sex differences in the levels of cortisol, 11-ketotestosterone, testosterone, and 17beta-estradiol in the sex-changing bluebanded goby Lythrypnus dalli. Steroid hormones were collected from water samples and analyzed by enzyme immunoassay. During the breeding season, hormones were(More)
1. The effects of raising extracellular potassium concentration ([K+]o) from 3.0 to 5.3, 9.5 or 16.8 mM on chemoreceptor responses to hypoxia, hypercapnia and asphyxia were examined in a superfused in vitro rat carotid body preparation. 2. Single-exponential functions with offset were fitted to the chemoreceptor discharge responses to ramp decreases in Po2.(More)
1. The effect of chronic hypoxaemia upon in vitro carotid body chemosensitivity was observed in eight rats > 5 weeks of age born and reared in 12% oxygen. Comparisons were made with eight age-matched normoxic rats. 2. Single exponential functions with offset were fitted to the normalized (percentage of maximum) discharge responses to ramp decreases in PO2(More)
PURPOSE To investigate whether an aggressive traffic violation enforcement program could reduce motor vehicle crashes (MVCs), injury collisions, fatalities, and fatalities related to speed, and decrease injury severity in crash victims treated at the trauma center. METHODS A vigorous enforcement program was established within Fresno, Calif, city(More)