Learn More
The recommendations set forth in this report are those of the Task Force Members and do not necessarily reflect the official position of the American College of Cardiology. ‡ Dr Shanti Mendis of the WHO participated in the task force in her personal capacity, but this does not represent WHO approval of this document at the present time. The content of this(More)
The recommendations set forth in this report are those of the Task Force Members and do not necessarily reflect the official position of the American College of Cardiology. *Co-chairpersons. †Dr Shanti Mendis of the World Health Organization participated in the task force in her personal capacity, but this does not represent WHO approval of this document at(More)
BACKGROUND The A10 and A7r5 cell lines derived from the thoracic aorta of embryonic rat are widely used as models of non-differentiated, neonatal and neointimal vascular smooth muscle cells in culture. The recent discovery of resident multipotent vascular stem cells within the vessel wall has necessitated the identity and origin of these vascular cells be(More)
Segments of peripheral nerve were autografted into the thalamus of adult rats. The peroneal nerve was used in one group, the tibial nerve (which has approximately twice the cross-sectional area of the peroneal nerve) in a second group, and two lengths of peroneal nerve side by side in a third group. Between 1 and 4 months later HRP was applied to the distal(More)
OBJECTIVE The purpose of this study was to determine the effect of cyclic strain on Notch signaling in endothelial cells. METHODS AND RESULTS Exposure of human endothelial cells (ECs) to cyclic strain (10%) resulted in temporal upregulation of Notch receptors (1 and 4) at the mRNA and protein level. Cyclic strain significantly increased EC network(More)
Vascular smooth muscle cell (SMC) fate decisions (cell growth, migration, and apoptosis) are fundamental features in the pathogenesis of vascular disease. We investigated the role of Notch 1 and 3 receptor signaling in controlling adult SMC fate in vitro by establishing that hairy enhancer of split (hes-1 and-5) and related hrt's (hrt-1,-2, and-3) are(More)
The Notch signaling pathway is critical for cell fate determination during embryonic development, including many aspects of vascular development. An emerging paradigm suggests that the Notch gene regulatory network is often recapitulated in the context of phenotypic modulation of vascular smooth muscle cells (VSMC), vascular remodeling, and repair in adult(More)
Notch signaling has been shown recently to regulate vascular cell fate in adult cells. By applying a uniform equibiaxial cyclic strain to vascular smooth muscle cells (SMCs), we investigated the role of strain in modulating Notch-mediated growth of SMCs in vitro. Rat SMCs cultured under conditions of defined equibiaxial cyclic strain (0% to 15% stretch; 60(More)
AIMS Our aims were to determine the effect of alcohol (EtOH) on endothelial angiogenic activity and to delineate the cell signalling mechanisms involved. METHODS AND RESULTS Treatment of human umbilical vein endothelial cells (HUVECs) with EtOH (1-100 mM, 24 h) dose-dependently increased their network formation on Matrigel (an index of angiogenesis) with(More)
Traditional representations of philosophy have tended to prize the role of reason in the discipline. These accounts focus exclusively on ideas and arguments as animating forces in the field. But anecdotal evidence and more rigorous sociological studies suggest there is more going on in philosophy. In this article, we present two hypotheses about social(More)