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We provide an updated version of the Compendium of Physical Activities, a coding scheme that classifies specific physical activity (PA) by rate of energy expenditure. It was developed to enhance the comparability of results across studies using self-reports of PA. The Compendium coding scheme links a five-digit code that describes physical activities by(More)
The British Regional Heart Study (BRHS) reported in 1986 that much of the inverse relation of high-density lipoprotein cholesterol (HDLC) and incidence of coronary heart disease was eliminated by covariance adjustment. Using the proportional hazards model and adjusting for age, blood pressure, smoking, body mass index, and low-density lipoprotein(More)
This report is one of a series produced by the CSIRO Division of Marine Research from a survey of the shallow reef and shoal fishery resources and habitats of the MOU74 Box off northwestern Australia. The authors wish to thank the captain and crew of the MV James Kirby for their dedication and assistance, and Des Pike (EA) and Tom Morris (WA Fisheries) for(More)
Although questions about social cohesion lie at the core of our discipline, definitions are often vague and difficult to operationalize. Here, research on social cohesion and social embeddedness is linked by developing a concept of structural cohesion based on network node connectivity. Structural cohesion is defined as the minimum number of actors who, if(More)
BACKGROUND Fine particulate matter (PM2.5) has been linked to cardiovascular disease, possibly via accelerated atherosclerosis. We examined associations between the progression of the intima-medial thickness (IMT) of the common carotid artery, as an indicator of atherosclerosis, and long-term PM2.5 concentrations in participants from the Multi-Ethnic Study(More)
For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of "the dose makes the poison," because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low dose and nonmonotonicity. Low-dose(More)
Topiramate (TPM) has shown efficacy in migraine prophylaxis in two large placebo-controlled, dose-ranging trials. We conducted a randomised, double-blind, multicentre trial to evaluate the efficacy and safety of two doses of topiramate vs placebo for migraine prophylaxis, with propranolol (PROP) as an active control. Subjects with episodic migraine with and(More)
Ambient levels of particulate matter have been linked to cardiovascular disease. The mechanisms mediating these associations are poorly understood. One candidate mechanism is inflammation. Using data from the Multi-Ethnic Study of Atherosclerosis (2000-2002), the authors investigated the relation between exposure to particulate matter of less than or equal(More)
BACKGROUND Open-label trials and small controlled studies report topiramate's efficacy in migraine prevention. OBJECTIVE To assess the efficacy and safety of topiramate as a migraine-preventive therapy. DESIGN A 26-week, randomized, double-blind, placebo-controlled study. SETTING Outpatient treatment at 49 US clinical centers. Patients Patients were(More)
BACKGROUND Low doses of some persistent organic pollutants (POPs) associate cross-sectionally with type 2 diabetes, whereas associations with high POP exposures are inconsistent. OBJECTIVES We investigated whether several POPs prospectively predict type 2 diabetes within the Coronary Artery Risk Development in Young Adults (CARDIA) cohort. METHODS(More)