Chromosomal instability (CIN) underlies malignant properties of many solid cancers and their ability to escape therapy, and it might itself cause cancer [1, 2]. CIN is sustained by deficiencies in proteins, such as the tumor suppressor p53 [3-5], that police genome integrity, but the primary cause of CIN in sporadic cancers remains uncertain [6, 7]. The… (More)
BACKGROUND Ipilimumab, a fully human monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4, has demonstrated an improvement in overall survival in two phase III trials of patients with advanced melanoma. The primary objective of the current trial was to prospectively explore candidate biomarkers from the tumor microenvironment for associations… (More)
We examine the D-3 brane from the point of view of the double dimensionally reduced M theory 5 brane on a torus. M-theory, IIB identifications are explicitly constructed and a possible reformulation of the D-3 brane is discussed. The du-ality transformation of the reduced 3-brane necessary to make the identification is discussed in detail.
In this note we investigate quantum aspects of the newly proposed theory of multiple membranes put forward by Bagger and Lambert. In particular we analyse the possibility of a finite renormalisation of the coupling at one loop.
We reformulate the Born-Infeld action, coupled to an axion and a dilaton in a duality manifest way. This action is the generalization of the Schwarz-Sen action for non-linear electrodynamics. We show that this action may be obtained by dimensional reduction on a torus of a self-dual theory in 6 dimensions. The dilaton-axion being identified with the complex… (More)
BACKGROUND Achieving high participation of communities representative of all sub-populations is needed in order to ensure broad applicability of biobank study findings. This study aimed to understand potentially mutable attitudes and opinions commonly correlated with biobank participation in order to inform approaches to promote participation in biobanks.… (More)
In this thesis, two versions of a Discrete Superconducting Vortex Flow Transistor (DVFT) are studied. Both overdamped and underdamped versions are fabricated with low Tc Niobium Josephson junctions. We present analytical models for the operation of the DVFTs that agree with the experimental data. In addition to the operational model of the DVFT, we also… (More)
Treatment with ipilimumab, a fully human anti-CTLA-4 antibody approved for the treatment of advanced melanoma, is associated with some immune-related adverse events (irAEs) such as colitis (gastrointestinal irAE, or GI irAE) and skin rash, which are managed by treatment guidelines. Nevertheless, predictive biomarkers that can help identify patients more… (More)
AIM Ipilimumab is a fully human, monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4. The objective of the present study was to characterize the clinical pharmacology profile of ipilimumab using a population pharmacokinetic (PPK) approach. METHODS The PPK model was developed using 2095 ipilimumab serum concentration values from 499 patients… (More)
This thesis presents a beat detection algorithm which combines both audio and visual inputs to synchronize a robotic musician to its human counterpart. Although there has been considerable work done to create sophisticated methods for audio beat detection, the visual aspect of musicianship has been largely ignored. With advancements in image processing… (More)