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Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal than comprehensive evidence. To this end, we compare two large compendia of transcriptional profiles of human and mouse immune cell(More)
DNA complementarity is expressed by way of three hydrogen bonds for a G:C base pair and two for A:T. As a result, careful control of the denaturation temperature of PCR allows selective amplification of AT-rich alleles. Yet for the same reason, the converse is not possible, selective amplification of GC-rich alleles. Inosine (I) hydrogen bonds to cytosine(More)
We sought to examine ADAR-1 editing of measles and influenza virus genomes derived from inactivated seasonal influenza and live attenuated measles virus vaccines grown on chicken cells as the culture substrate. Using highly sensitive 3DI-PCR (R. Suspène et al., Nucleic Acids Res. 36:e72, 2008), it was possible to show that ADAR-1 could hyperdeaminate(More)
Après un an d’internat en oncologie médicale à Paris, j’ai décidé en septembre 2011 de partir aux États-Unis, à Boston, pour entrer dans le programme de thèse de sciences d’Harvard Medical School. Je pense sincèrement que je manque de recul pour avoir une discussion objective, critique et constructive de la recherche médicale aux États-Unis. Je n’en suis(More)
The sole dysregulation of the cell cycle’s molecular program does not explain the uncontrolled growth of cancer cells. Metabolism adaptation is also required. When differentiated (quiescent) cells depend on lactic fermentation in the absence of oxygen (and mitochondrial respiration when oxygen is present), cancer cells rely on lactic fermentation(More)
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