David Plowman

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We investigated 106 home hemodialysis patients whose mean [+/- SEM] serum aluminum (Al) concentration was 60.9 +/- 4.1 micrograms/liter. Serum Al concentration was inversely related to daily urine output (r = -0.52, P less than 0.001). Urine volume and measurements of Al exposure were included in a multivariate analysis of serum Al concentration in the 62(More)
13 of 100 consecutive isolates of Haemophilus influenza obtained from respiratory specimens over the six months to June, 1979, had diminished sensitivity to ampicillin. 6 of the 13 strains produced beta-lactamase, whilst the remaining 7 had no evidence of this enzyme, either in whole cells or in extracts prepared by sonication. The minimum inhibitory(More)
To investigate the possibility that aluminium may exacerbate anaemia in dialysis patients with only modest aluminium accumulation, 15 patients whose exposure to aluminium had been low were treated for three months with the aluminium chelating agent desferrioxamine, 30 mg/kg intravenously at the end of each dialysis session. Serum aluminium concentrations(More)
A class of temperature-sensitive (ts) mutants of T4 lysozyme with reduced activity at 30 degrees C and no activity at 43 degrees C has been selected. These mutants, designated "tight" ts mutants, differ from most other T4 lysozyme mutants that are active at 43 degrees C, but only manifest their ts lesion by a reduced halo size around phage plaques after(More)
BACKGROUND Aluminium toxicity in dialysis patients is well described. Aluminium has a close chemical affinity with silicon. Silicon may have a role in protection against aluminium toxicity. METHODS We measured serum aluminium and silicon levels from haemodialysis patients from four different centres. RESULTS Though no relationship was seen across all(More)
A healthy 20-year-old woman, belonging to the Kgalagadi tribe of Botswana, has been found to possess a variant Haemoglobin A2 as her only minor haemoglobin component. Fingerprinting and amino-acid analysis have shown that it is Haemoglobin A2' (delta 16 Gly----Arg). The one parent available for study is heterozygous for the Hb delta A2' allele and the(More)
Surface-water treatment plants provide water to approximately 67 percent of the residents of Pennsylvania. Industrial activities and agricultural practices significantly contribute to the chemical and microbiological load of surface-water systems. For the study reported here, surface water from three sites along Two Lick Creek in Indiana County in(More)
The case under examination is an example of a family with Hb J Rovigo interacting with beta thalassemia. Such hemoglobin has the same mobility as J haemoglobin, and the analysis of amino acids showed it to be a variant of the alpha 53 (E2) Alanine-Aspartic chain. The percentage of haemoglobin ranged from around 22.7 to 30.5%.