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5-amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease.
These oral NP formulations demonstrated their therapeutic potential and appear to be an interesting approach for the therapy of inflammatory bowel disease. Expand
Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.
A new spirostanol saponin was isolated from the two synonymous species, Solanum incanum and S. heteracanthum, by using a combination of 1D and 2D NMR techniques and by mass spectrometry. Expand
The targeting of surface modified silica nanoparticles to inflamed tissue in experimental colitis.
5-Amino salicylic acid loaded silica nanoparticles (SiNP) are proposed here as drug delivery system for specific accumulation in inflamed colonic tissues allowing for selective medication delivery to such inflammation sites. Expand
Triterpenoid saponins from the roots of two Gypsophila species.
Two triterpenoid saponins with two known ones have been isolated from the roots of Gypsophila arrostii var. nebulosa, and two new ones from the roots of Gypsophila bicolor. Their structures wereExpand
Triterpene Saponins from Cyclamen persicum
A new triterpene saponin 3-O-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranoyl-16α-hydroxy-13β,28-epoxy-oleanan-30-al was isolated from Cyclamen persicum and cytotoxicity of compounds 2 and 4 was evaluated using two human colon cancer cell lines HT-29 and HCT 116. Expand
Triterpenoid saponins from the roots of Spergularia marginata.
The structures of four previously undescribed triterpenoid saponins, a known one and one spinasterol glycoside, were established by extensive NMR and mass spectroscopic techniques and evaluated against two human cancer cell lines SW480 and MCF-7. Expand
cis-Dichloroplatinum(II) complexes tethered to dibenzo[c,h][1,6]naphthyridin-6-ones: synthesis and cytotoxicity in human cancer cell lines in vitro.
A novel family of cisplatin-type complexes tethered to dibenzo[c,h][1,6]naphthyridin-6-one topoisomerase inhibitor via a polymethylene chain and their nonplatinated counterparts were prepared, and molecules containing the tri- and hexamethylene chain length were the most cytotoxic. Expand
Terpenoid glycosides from the root's barks of Eriocoelum microspermum Radlk. ex Engl.
Eight undescribed triterpenoid saponins together with a known one, and two undescribed sesquiterpene glycosides were isolated from root's barks of Eriocoelum microspermum. Their structures wereExpand
New pregnane and phenolic glycosides from Solenostemma argel.
Three new pregnane glycosides with two known ones and a new phenolic glycoside have been isolated and showed a significant antioxidant potential with ORAC values in the concentration range 3481-9617μmoleq. Expand
A New Aromatic Compound from the Stem Bark of Terminalia catappa
A new aromatic compound 3,4,5-trimethoxyphenyl-1-O-(4-sulfo)-β-D-glucopyranoside (1) has been isolated from the barks of Terminalia catappa and its cytotoxicity and anti-inflammatory activity, together with the antioxidant capacity of compound 1 were evaluated. Expand