David Perez-Morga

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Multiple phosphatidylinositol (PtdIns) 3-kinases (PI3Ks) can produce PtdIns3P to control endocytic trafficking, but whether enzyme specialization occurs in defined subcellular locations is unclear. Here, we report that PI3K-C2α is enriched in the pericentriolar recycling endocytic compartment (PRE) at the base of the primary cilium, where it regulates(More)
  • N Schiffmann, Chavez K M Azdad, Bishop D P, Wetzelear P, Marescau B, Gall D +64 others
  • 2010
Homeostatic plasticity of striatal neurons intrinsic excitability following dopamine depletion. PLoS ONE 4(9): e6908. Effects of maternal alcohol consumption during breastfeeding on motor and cerebellar Purkinje cells behavior in mice. CALLEWAERT: Differential contribution of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1 to chloride handling in rat embryonic(More)
During the last 10 years, much progress has been made in understanding signal transduction. However, the function of many newly identified proteins remains unknown. The protein/protein interactions have emerged as a major biochemical mechanism of signal transduction. They are of major interest to elucidate the role of a protein in one or another cellular(More)
BACKGROUND Microparticles (MPs), also called microvesicles (MVs) are plasma membrane-derived fragments with sizes ranging from 0.1 to 1μm. Characterization of these MPs is often performed by flow cytometry but there is no consensus on the appropriate negative control to use that can lead to false positive results. MATERIALS AND METHODS We analyzed MPs(More)
Objective PI3K-C2a is a regulator of vesicle recycling at the base of the primary cilium and is required for the targeting of ciliary components. Here we sought to understand whether PI3K-C2a is required for the targeting of Poly-cystin-2 to primary cilia and the consequent regulation of kidney cyst formation. Methods Homozygous mutation of Pik3c2a, the(More)
The early stages of clot formation in blood vessels involve platelets adhesion-aggregation. Although these mechanisms have been extensively studied, gaps in their understanding still persist. We have performed detailed in-vitro experiments and developed a numerical model to better describe and understand this phenomenon. Unlike previous studies, we took(More)
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