David P. Gurka

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  • Anand Kumar, Daniel Roberts, +10 authors Mary Cheang
  • Critical care medicine
  • 2006
OBJECTIVE To determine the prevalence and impact on mortality of delays in initiation of effective antimicrobial therapy from initial onset of recurrent/persistent hypotension of septic shock. DESIGN A retrospective cohort study performed between July 1989 and June 2004. SETTING Fourteen intensive care units (four medical, four surgical, six mixed(More)
UNLABELLED BACKGROUND Underfeeding of patients reliant on enteral tube feedings most likely is due primarily to interruptions in the infusions. Strategies to improve energy intake require an understanding of such interruptions and associated outcomes. OBJECTIVES To compare daily energy intake with goal energy intake; to ascertain frequency, duration, and(More)
BACKGROUND Despite extensive use of enteral (EN) and parenteral nutrition (PN) in intensive care unit (ICU) populations for 4 decades, evidence to support their efficacy is extremely limited. METHODS A prospective randomized trial was conducted evaluate the impact on outcomes of intensive medical nutrition therapy (IMNT; provision of >75% of estimated(More)
BACKGROUND Septic shock is a highly inflammatory and procoagulant state associated with significant mortality. In a single randomized controlled trial, recombinant human activated protein C (drotrecogin alfa) reduced mortality in patients with severe sepsis at high risk of death. Further clinical trials, including a recently completed trial in patients with(More)
BACKGROUND Acute hemorrhagic leukoencephalopathy (AHLE) is a rare condition associated with H1N1. In this condition the infection triggers an autoimmune response which results in perivascular demyelination and hemorrhage in the brain parenchyma. METHODS We report a case of a patient who developed brain edema and herniation as a result of AHLE. RESULTS A(More)
BACKGROUND Nurses are often responsible for placement of large-bore gastric tubes. Tube misplacement into the lungs is a potential complication with serious sequelae. The reliability of common bedside methods for differentiating between pulmonary and gastric placement has not been acceptable. OBJECTIVE To compare the accuracy of capnometry (colorimetric(More)
BACKGROUND/OBJECTIVES The detection of malnutrition in the intensive care unit (ICU) is critical to appropriately address its contribution on outcomes. The primary objective of this investigation was to determine if nutritional status could be reliably classified using subjective global assessment (SGA) in mechanically ventilated (MV) patients. (More)
Patients requiring mechanical ventilation in an intensive care unit commonly fail to attain enteral nutrition (EN) infusion goals. We conducted a cohort study to quantify and compare the percentage of energy and protein received between standard care (n=24) and intensive medical nutrition therapy (MNT) (n=25) participants; to assess the percentage of energy(More)
PURPOSE OF REVIEW Severe sepsis and septic shock are common causes of morbidity and mortality in critically ill patients. The complexities of the septic cascade continue to emerge and may identify new targets for innovative patient management. This review will highlight some of the recent advances in our management of the patient with sepsis. RECENT(More)
Despite the fact that current international guidelines suggest initiation of antimicrobial therapy within an hour of presentation with severe sepsis and septic shock, no clinical studies exist to support this recommendation (1). In reality, initiation of antimicrobial therapy for infections causing critical illness often awaits thorough clinical evaluation,(More)