David O. Cooney

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Amoco Grade PX-21 powdered activated charcoal was found to adsorb nearly three times as much sodium salicylate from simulated gastric fluid than did another charcoal (Norit A), which is representative of the best of all other charcoals heretofore available. This indicates the potential superior effectiveness of the Amoco charcoal as an oral antidote in(More)
  • D O Cooney
  • Journal of toxicology. Clinical toxicology
  • 1982
The effect of the type of carboxymethylcellulose (CMC) and amount of CMC used in preparing antidotal charcoal formulations on the in vitro kinetics of sodium salicylate adsorption from simulated gastric fluid was assessed in agitated vessels of two designs. Mixtures made with low, medium, and high viscosity CMC were tested. Additionally, the effects of the(More)
  • D O Cooney
  • Journal of toxicology. Clinical toxicology
  • 1995
Four commercially available antidotal activated charcoal suspensions (Actidose Aqua, InstaChar, LiquiChar, and CharcoAid 2000) were evaluated with respect to their abilities to adsorb three test drugs in vitro from simulated gastric fluid. Different volumes of each suspension were added to glass vials containing 20 mL of stock solutions of each drug. The(More)
Colobus monkeys on the African island of Zanzibar eat charcoal from burned trees and lying near kilns, where it is produced for cooking. This behavior may be a learned response for counteracting toxicity due to phenolic and similar compounds that occur in significant concentrations in the Indian almond (Terminalia catappa) leaves and mango (Mangifera(More)
The Zanzibar red colobus monkey is the only primate, aside from humans, known to eat charcoal in the wild. All age classes and both sexes eat charcoal, but only those groups living in perennial gardens or near human dwellings do so. The habit appears to be transmitted from mother to offspring by imitation, but how it developed in the first place is unknown.(More)
  • D O Cooney
  • American journal of hospital pharmacy
  • 1980
The palatabilities of thickened activated charcoal formulations flavored with sucrose, sorbitol or saccharin sodium were compared. Three flavored activated charcoal formulations were prepared from a base of 25 g of activated charcoal, 1.5 g of carboxymethylcellulose, and 75 g of distilled water. The ratios of sweetener to activated charcoal were 1:1 for(More)
The efficacy of sucrose as a flavor for activated charcoal was studied. In vitro adsorption of sucrose (in Simulated Gastric Fluid, USP, without pepsin) to activated charcoal, and of a 1-g/liter sodium salicylate solution to a 1:1 mixture of sucrose and activated charcoal and to plain activated charcoal, was measured spectrophotometrically. In vitro(More)
Drug adsorption studies were carried out using three charcoal-based and one resin-based hemoperfusion devices. They were the Sandev Hemocol unit, the Gambro Adsorba 300C unit unit, the Becton-Dickinson Hemodetoxifier, and the Extracorporeal Medical Specialties XR-010 Hemoperfusion column, respectively. Clearance versus time tests of up to six hours duration(More)
We studied the adsorption of fluoxetine HCl (Prozac) by Norit USP XXIII activated charcoal in vitro, in simulated gastric fluid (USP; pH 1.2), and in simulated intestinal fluid (USP; pH 7.5). The data were fitted to both Langmuir and Freundlich equations. The Langmuir Qm values (maximal adsorption capacities) for pH 1.2 and 7.5 were 0.258 and 0.330 g drug/g(More)