David Nicol

Learn More
Delay Tolerant Networking (DTN) considers how to provide communication in contexts where it is unreasonable to assume end-to-end connectivity. Network devices exchange buffered messages when they come into communication range; messages may be buffered and carried physically several times before ultimately being received. Service characteristics of a DTN(More)
The use of technology with engineering design students is well established, with shared workspaces being particularly supportive of the collaborative design process. This paper reports on a study where a design knowledge framework involving three learning loops was used to analyse the effectiveness of shared workspaces and digital repositories in supporting(More)
Concerns about noncompletion and the quality of the 1st-year student experience have been linked to recent changes in higher education such as modularisation, increased class sizes, greater diversity in the student intake and reduced resources. Improving formative assessment and feedback processes is seen as one way of addressing academic failure, of(More)
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are unclear. In this study, we analyzed somatic alterations in mtDNA from 1675 tumors. We identified 1907 somatic(More)
The expectations E[X (1) ], E[Z (1) ], and E[Y (1) ] of the minimum of n independent geometric, modified geometric, or exponential random variables with matching expectations differ. We show how this is accounted for by stochastic variability and how E[X (1) ]/E[Y (1) ] equals the expected number of ties at the minimum for the geometric random variables. We(More)
  • Rosalie Fisher, Stuart Horswell, Andrew Rowan, Maximilian P Salm, Elza C de Bruin, Sakshi Gulati +29 others
  • 2014
Genomic analysis of multi-focal renal cell carcinomas from an individual with a germline VHL mutation offers a unique opportunity to study tumor evolution. We perform whole exome sequencing on four clear cell renal cell carcinomas removed from both kidneys of a patient with a germline VHL mutation. We report that tumors arising in this context are clonally(More)
  • Suzanne K Chambers, Megan Ferguson, RA Gardiner, David Nicol, Louisa Gordon, Stefano Occhipinti +1 other
  • 2008
BACKGROUND Prostate cancer is the most common male cancer in the Western world but is highly heterogeneous in disease progression and outcomes. Consequently, the most substantial morbidity may actually arise from the adverse psychosocial impact of distress in decision-making and long term quality of life effects such as impotence. This paper presents the(More)
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched for signatures of ionizing radiation in 12 radiation-associated second malignancies of different tumour types. Two signatures of(More)