The authors administered 45-90 mg/day of tacrine to eight patients with tardive dyskinesia. After 2 weeks of treatment, there was a mean reduction in tardive dyskinesia scores of 43%. No improvement occurred when a placebo was used instead of tacrine.
The monoamine oxidase inhibitors (MAOI) and the tricyclic antidepressants (TCA) have been used for over 20 years, and another generation of antidepressants has now emerged. Only mianserin is available in Australia but viloxazine, clomipramine, nomifensine, maprotiline, iprindole and zimelidine have been used overseas for several years.