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Plans and situated actions: The problem of human-machine interaction Lucy Suchman Situated learning: Legitimate peripheral participation Jean Lave and Etienne Wenger Street mathematics and school mathematics Library of Congress Cataloging-in-Publifation Data Distributed cognitions : psychological and educational considerations / edited by Gavriel Salomon,(More)
This paper was written as part of a project funded by the John D. and Catherine T. MacArthur Foundation. The authors thank the foundation for its help, adding the standard disclaimer that the ideas expressed here do not necessarily reflect the position or policy of supporting agencies. We also thank Carlos Vasco for working through a number of the concepts(More)
Intensive (longer and more frequent) hemodialysis has emerged as an alternative to conventional hemodialysis for the treatment of patients with end-stage renal disease. However, given the differences in dialysis delivery and models of care associated with intensive dialysis, alternative approaches to patient management may be required. The purpose of this(More)
Proteomic profiling using mass spectrometry (MS) is one of the most promising methods for the analysis of complex biological samples such as urine, serum and tissue for biomarker discovery. Such experiments are often conducted using MALDI-TOF (matrix-assisted laser desorption/ionisation time-of-flight) and SELDI-TOF (surface-enhanced laser(More)
A database of 5448 peptide tandem mass spectra acquired in a quadrupole time-of-flight mass spectrometer was generated for peptides derived from proteins digested with trypsin. Peptides were identified from their mass spectra by the Mascot algorithm. Statistical models were then used to investigate factors influencing the abundance of ions formed. Separate(More)
Normalisation of data to minimise the impact of technical variation on comparative sample analysis is often carried out. Using SELDI data as a model, we have examined the effects of normalisation by TIC which is commonly used for MS data. Significant intergroup differences in normalisation factor were found for serum profiles which could not be explained by(More)
BACKGROUND Practices in vascular access management with intensive hemodialysis may differ from those used in conventional hemodialysis. STUDY DESIGN We conducted a systematic review to inform clinical practice guidelines for the provision of intensive hemodialysis. SETTING & POPULATION Adult patients receiving maintenance (>3 months) intensive(More)