David N. Perkins

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This paper was written as part of a project funded by the John D. and Catherine T. MacArthur Foundation. The authors thank the foundation for its help, adding the standard disclaimer that the ideas expressed here do not necessarily reflect the position or policy of supporting agencies. We also thank Carlos Vasco for working through a number of the concepts(More)
This paper is based on the results of research carried out during the first year and a half of the Understandings of Consequence Project. We are continuing to research and develop the ideas presented here. If you have feedback for us or would like to keep in touch with developments on the project, please check our website atPrincipal Investigators. Any(More)
Normalisation of data to minimise the impact of technical variation on comparative sample analysis is often carried out. Using SELDI data as a model, we have examined the effects of normalisation by TIC which is commonly used for MS data. Significant intergroup differences in normalisation factor were found for serum profiles which could not be explained by(More)
The ability to discriminate whether pictured box shapes (parallelopipeds) are projections of three-dimensional rectangular forms has been demonstrated by Perkins and Cooper in US populations and interpreted as a symptom of a general Gestalt strategy in perception. Deregowski suggested earlier that this perceptual strategy might not appear as strongly in(More)
Principal Investigators. Any opinions, findings, conclusions or recommendations expressed here are those of the authors and do not necessarily reflect the views of the National Science Foundation. 2 Overview Scientifically accepted explanations often require students to structure knowledge in ways that contradict their expectations about the nature of how(More)
Student lawyers are among the most intelligent of students in the psychometric sense. They are able dedicated learners who have passed the hurdles of earlier education with excellent records. Moreover, good reasoning in terms of claims and evidence is central to their enterprise. Lawyers—student or professional—need to consider not only the side of the case(More)
BACKGROUND Proteomic profiling using mass spectrometry (MS) is one of the most promising methods for the analysis of complex biological samples such as urine, serum and tissue for biomarker discovery. Such experiments are often conducted using MALDI-TOF (matrix-assisted laser desorption/ionisation time-of-flight) and SELDI-TOF (surface-enhanced laser(More)