David N. Chi

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Breast cancer is a heterogeneous disease and can be classified based on gene expression profiles that reflect distinct epithelial subtypes. We identify prostate-derived ETS factor (PDEF) as a mediator of mammary luminal epithelial lineage-specific gene expression and as a factor required for tumorigenesis in a subset of breast cancers. PDEF levels strongly(More)
Although poly(ADP-ribose) polymerase (PARP) inhibitors are active in homologous recombination (HR)-deficient cancers, their utility is limited by acquired resistance after restoration of HR. Here, we report that dinaciclib, an inhibitor of cyclin-dependent kinases (CDKs) 1, 2, 5, and 9, additionally has potent activity against CDK12, a transcriptional(More)
Stewart-Treves syndrome is a rare cutaneous angiosarcoma with a poor prognosis. Physicians must be aware of this lethal syndrome, especially in patients who have been treated for breast cancer with radiation and lymph-node dissection (such as the case reported here). Patients who develop unexplained enlarging plaques of coalescing purple papules should have(More)
INTRODUCTION: Rhytidectomy is one of the most commonly performed cosmetic procedures by plastic surgeons. Increasing attention to the development of a high-value, low-cost healthcare system is a priority of U.S. healthcare policy makers as projections of healthcare costs in the U.S. are shown to be unsustainable. This study aims to analyze specific patient(More)
RESULTS: From 2000–2013 the proportion of female surgeons among all female physicians has remained constant at 12–13%. The ratio of femaleto-male surgeons and residents has increased over time in all surgical specialties. While females outnumber males in one surgical specialty (obstetrics and gynecology), the female-to-male ratio in neurosurgery, orthopedic(More)
Rhytidectomy is one of the most commonly performed cosmetic procedures by plastic surgeons. Increasing attention to the development of a high-value, low-cost healthcare system is a priority in the USA. This study aims to analyze specific patient and hospital factors affecting the cost of this procedure. We conducted a retrospective cohort study of self-pay(More)
RCSN-3 cells are a cloned cell line derived from the substantia nigra of an adult rat. The cell line grows in monolayer and does not require differentiation to express catecholaminergic traits, such as (i) tyrosine hydroxylase; (ii) dopamine release; (iii) dopamine transport; (iv) norepinephrine transport; (v) monoamine oxidase (MAO)-A expression, but not(More)
A user model (UM) contains information about users, such as users' goals, beliefs, knowledge, preferences, and capabilities. A discourse model (DM) contains information about the conversation, such as the linguistic structure, the attentional state, and the intentional structure [Grosz and Sidner 1986). Given these definitions, I will argue that the UM(More)
Crowdsourcing the Natural Breast in EthnicallyDiverse Women: Population Preferences (Article begins on next page) The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Citation Bucknor, Alexandra, Austin D. Chen, Parisa Kamali, Anmol S. Chattha, Charlotte van Veldhuisen, Olivier(More)
While the multiple endocrine neoplasia type 1 (MEN1) gene functions as a tumor suppressor in a variety of cancer types, we explored its oncogenic role in breast tumorigenesis. The MEN1 gene product menin is involved in H3K4 trimethylation and co-activates transcription. We integrated ChIP-seq and RNA-seq data to identify menin target genes. Our analysis(More)
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