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Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).
The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) andExpand
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Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist.
The long chain free fatty acid receptor 4 (FFA4/GPR120) has recently been recognized as lipid sensor playing important roles in nutrient sensing and inflammation and thus holds potential as aExpand
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Functional Screening in the Melanophore Bioassay
The melanophore bioassay is a robust, sensitive, and versatile procedure for screening G protein–coupled receptors in a variety of formats. Because melanophores contain a wide variety of G proteins,Expand
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Identification of nonabsorbable inhibitors of the scavenger receptor-BI (SR-BI) for tissue-specific administration.
The identification of a low-permeability scavenger receptor BI (SR-BI) inhibitor starting from the ITX-5061 template is described. Structure-activity and structure-permeability relationships wereExpand
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CROSSBRED BARBADOS BLACKBELLY SHEEP 1
Resistance to l laemonchus contortus infection was studied in two experiments conducted with 52 lambs of widely different genetic background. Breed groups compared were: Dorset (D), BarbadosExpand
PARASITE RESISTANCE IN S T R A I G H T B R E D A N D CROSSBRED BARBADOS B L A C K B E L L Y SHEEP 1 ,2
Resistance to gastrointestinal parasites was studied in a total of 193 sheep with widely different points of origin and genetic backgrounds. Breed groups compared were Dorset (D), Barbados BlackbellyExpand