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Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry.

• Marlene P Freeman, Joseph R Hibbeln, +8 authors Andrew L. Stoll
• The Journal of clinical psychiatry
• 2006

OBJECTIVE To determine if the available data support the use of omega-3 essential fatty acids (EFA) for clinical use in the prevention and/or treatment of psychiatric disorders. PARTICIPANTS The… (More)

Quality of life assessments in major depressive disorder: a review of the literature.

• George I. Papakostas, Timothy J. Petersen, Yasmin Mahal, David Mischoulon, Andrew Nierenberg, Maurizio Fava
• General hospital psychiatry
• 2004

According to the DSM-IV classification, a diagnosis of Major Depressive Disorder (MDD) is possible only when there is evidence of significant inference with functioning. However, despite the high… (More)

L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials.

• George I. Papakostas, Richard Charles Shelton, +16 authors Maurizio Fava
• The American journal of psychiatry
• 2012

OBJECTIVE The authors conducted two multicenter sequential parallel comparison design trials to investigate the effect of L-methylfolate augmentation in the treatment of major depressive disorder in… (More)

Inflammation as a Predictive Biomarker for Response to Omega-3 Fatty Acids in Major Depressive Disorder: A Proof of Concept Study

• Mark Hyman Rapaport, Andrew Nierenberg, +4 authors David Mischoulon
• Molecular Psychiatry
• 2016

This study explores whether inflammatory biomarkers act as moderators of clinical response to omega-3 (n-3) fatty acids in subjects with major depressive disorder (MDD). One hundred fifty-five… (More)

Are omega-3 fatty acids antidepressants or just mood-improving agents? The effect depends upon diagnosis, supplement preparation, and severity of depression

• P. -Y. Lin, David Mischoulon, +4 authors K-P Su
• Molecular Psychiatry
• 2012

The use of omega-3 fatty acids for depression treatment is of considerable interest, in part due to the inadequate efficacy and tolerability of standard antidepressant medications. Although several… (More)

A double-blind, placebo-controlled study of aripiprazole adjunctive to antidepressant therapy among depressed outpatients with inadequate response to prior antidepressant therapy (ADAPT-A Study).

• Maurizio Fava, David Mischoulon, +7 authors Mark H. Pollack
• Psychotherapy and psychosomatics
• 2012

BACKGROUND We assessed the efficacy of low-dose aripiprazole added to antidepressant therapy (ADT) in major depressive disorder (MDD) patients with inadequate response to prior ADT. METHODS As per… (More)

S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial.

• George I. Papakostas, David Mischoulon, Irene Shyu, Jonathan E. Alpert, Maurizio Fava
• The American journal of psychiatry
• 2010

OBJECTIVE Despite the progressive increase in the number of antidepressants, many patients with major depressive disorder continue to be symptomatic. Clearly, there is an urgent need to develop… (More)

The pharmacologic management of SSRI-induced side effects: a survey of psychiatrists.

• Christina M Dording, David Mischoulon, +5 authors Maurizio Fava
• Annals of clinical psychiatry : official journal…
• 2002

Despite the superior side effect profile of the newer antidepressants over the tricyclics and monoamine oxidase inhibitors, all newer antidepressants are associated with a wide array of side effects.… (More)

Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study.

• Dawn Ionescu, Michaela Ballentyne Swee, +11 authors Cristina Cusin
• The Journal of clinical psychiatry
• 2016

BACKGROUND Ketamine rapidly reduces thoughts of suicide in patients with treatment-resistant depression who are at low risk for suicide. However, the extent to which ketamine reduces thoughts of… (More)

Nutritional medicine as mainstream in psychiatry.

• Jerome Sarris, Alan C. Logan, +14 authors Felice N Jacka
• The lancet. Psychiatry
• 2015

Psychiatry is at an important juncture, with the current pharmacologically focused model having achieved modest benefits in addressing the burden of poor mental health worldwide. Although the… (More)

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