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The authors and the Pew Center would like to thank the many reviewers for their time and expertise. The authors would also like to acknowledge the support provided by the Pew Center, particularly Steve Seidel's insightful contribution to the policy discussion and the valuable advice and guidance provided by Sanjana Ahmad and Judi Greenwald. Any remaining(More)
Cytochrome oxidase is the mitochondrial enzyme that catalyzes the utilization of oxygen for the electron transport chain during cellular respiration. Chronic subcutaneous infusion of sodium azide, an inhibitor of cytochrome oxidase, produced a spatial memory retention deficit in rats in a holeboard maze. Methylene blue, which has been shown to increase(More)
STUDY OBJECTIVES We evaluated the dosing requirements in argatroban-treated patients with heparin-induced thrombocytopenia (HIT) and hepatic dysfunction, and compared efficacy and safety outcomes with historical control patients. DESIGN Retrospective analysis. SETTING Inpatient setting. PATIENTS Patients with hepatic dysfunction, defined as total(More)
In a relatively short space of time Eastern Europe has become one of the principal source regions of migrants to the UK and citizens from these states now constitute some of the largest foreign-born populations in the country. This paper focuses on these trends from the perspective of UK employers and labour providers. Three main topics are covered; 1. The(More)
For more than a decade, the target of keeping global warming below 2 °C has been a key focus of the international climate debate. In response, the scientific community has published a number of scenario studies that estimate the costs of achieving such a target. Producing these estimates remains a challenge, particularly because of relatively well known,(More)
Methylene blue (MB) is a metabolic enhancer that has been demonstrated to improve memory retention when given post-training in low doses in a variety of tasks in rats, including inhibitory avoidance, spatial memory (in both normal and metabolically-impaired subjects), object recognition, and habituation to a familiar environment. MB has been also shown to(More)
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California has taken a leading role in regulating greenhouse gas (GHG) emissions, requiring that its economy-wide emissions be brought back down to the 1990 level by 2020. The state also has a long-term, aspirational goal of an 80 percent reduction below the 1990 level by 2050. While the steps needed to achieve the near-term target have already been clearly(More)
Over the next fifty years the potential impact on human livelihoods of environmental change could be considerable. One possible response may be increased levels of human mobility. This paper offers a first quantification of the levels of environmental migration to the United Kingdom that might be expected. The authors apply Bijak and Wiśniowski's (2010)(More)
We model the California Energy System to 2050 under policy and technology scenarios. The model optimizes technology and resource investments to meet emissions targets. Deep emissions cuts (474%) are achieved across all reduction scenarios. Carbon capture enables negative emission biofuels and allows more petroleum use. Greenhouse gas mitigation cost is(More)