David Martínez Hernández

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OBJECTIVE To examine the effectiveness of switching patients to lurasidone using 3 different dosing strategies. METHOD Adults with DSM-IV-defined schizophrenia or schizoaffective disorder in a nonacute phase of illness were randomized to 1 of 3 lurasidone dosing regimens for the initial 2 weeks of the study: (1) 40 mg/d for 2 weeks; (2) 40 mg/d for 1(More)
This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available(More)
OBJECTIVE To evaluate the effectiveness of lurasidone as maintenance treatment for schizophrenia. METHOD Adults experiencing an acute exacerbation of schizophrenia initially received 12-24 weeks of open-label treatment with lurasidone (40-80 mg/d, flexibly dosed). Patients who maintained clinical stability for ⩾12 weeks were randomized in double-blind(More)
Aging is considered to be driven by the so called senescence pathways, especially the mTOR route, although there is almost no information on its activity in aged tissues. Aging also induces Ca²⁺ signal alterations, but information regarding the mechanisms for these changes is almost inexistent. We investigated the possible involvement of the mTOR pathway in(More)
The aim of this study was to evaluate the short-term efficacy and safety of lurasidone in treating irritability associated with autistic disorder. In this multicenter trial, outpatients age 6-17 years who met DSM-IV-TR criteria for autistic disorder, and who demonstrated irritability, agitation, and/or self-injurious behaviors were randomized to 6 weeks of(More)
OBJECTIVE To evaluate optical rhinometry (ORM) using nasal provocation testing (NPT) as an objective tool to diagnose fungal allergic rhinitis (AR). STUDY DESIGN Prospective. SETTING Tertiary academic center. METHODS We prospectively enrolled healthy controls (HCs) and subjects with a clinical history of AR and positive skin prick test to Alternaria(More)
INTRODUCTION The consumption of antibiotics for systemic use has been well studied. However, data of topical use in our country are an anecdotal reference in the literature. OBJECTIVE To evaluate the outpatient use of topical antimicrobials in Spain associated with other drugs during the period December 2005 and November 2007. METHODS A descriptive(More)
The objectives of this study were to evaluate the degree of concordance between specialists (physicians) in relation to the process of medical care of patients with amebic liver abscess and to elaborate a model that contains the minimum elements considered as indispensable for the diagnosis, treatment and follow-up of an illness, based on the consensus of(More)
We examined trends and associated factors of disability among Spanish elderly with diabetes from data of three National Health Surveys (NHS) from 2000 to 2007. Prevalence of disability was higher among diabetic elderly versus non-sufferers and increased over time. Adjusted OR for activities of daily living 1.66 (1.37-2.00); instrumental activities of daily(More)
In liver cirrhosis, elevated levels of NO and ROS (reactive oxygen species) might greatly favour the generation of peroxynitrite. Peroxynitrite is a highly reactive oxidant and it can potentially alter the vascular reactivity and the function of different organs. In the present study, we evaluated whether peroxynitrite levels are related to the progression(More)