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OBJECTIVE Benign and malignant tumors of the spine significantly impair the function and quality of life of many patients. Standard treatment options, including conventional radiotherapy and surgery, are often limited by anatomic constraints and previous treatment. Image-guided stereotactic radiosurgery using the CyberKnife system (Accuray, Inc., Sunnyvale,(More)
The primary function of wireless sensor networks is data acquisition or monitoring of some medium, such as temperature. In many instances these networks are deployed throughout inaccessible or hazardous regions meaning frequent maintenance such as battery replacement is undesirable and in some cases impossible. Intelligent power management for these devices(More)
Fracture healing is a complex physiological process. With the latest advances made in molecular biology and genetics it is now known that it involves the spatial and temporal coordinated action of several different cell types, proteins and the expression of hundreds of genes working towards restoring its structural integrity without scar formation. The(More)
Treatment of critical size bone defects is a clinical problem often encountered in young patients following severe open limb injuries. If bone growth fails then a variable degree of morbidity may prevail with the end point being amputation of the limb. In addition the demographic challenges of an increasingly aging population dictate the need for innovative(More)
SUMMARY In the Trauma and Orthopaedic discipline, tissue engineering attempts to convert scientific knowledge into new products and methods of treatment in order to advance the repair, replacement, or regeneration of tissues such as bone, cartilage, tendon and ligament. Currently, tissue engineering strategies are based mainly on cell and tissue-based(More)
Computational protein design is a reverse procedure of protein folding and structure prediction, where constructing structures from evolutionarily related proteins has been demonstrated to be the most reliable method for protein 3-dimensional structure prediction. Following this spirit, we developed a novel method to design new protein sequences based on(More)
Following his last edition of the Origin of Species in 1872, Darwin spent much of the rest of his life searching for possible mechanisms, such as the pangenes in the blood, which would communicate information from the environment to the genome. In each of his six editions of the 'Origin', he stated that there were two forces in evolution - natural selection(More)
Pre-clinical studies indicate that pharmacologic agents can augment fracture union. If these pharmacologic approaches could be translated into clinical benefit and offered to patients with osteoporosis or patients with other risks for impaired fracture union (e.g. in subjects with large defects or open fractures with high complication rate), they could(More)
Interpolation is a technique used to estimate the value of a function at a given location, assuming that the values of the function are known for surrounding locations. A Wireless Sensor Network (WSN) is a spatially distributed set of sensor platforms usually with a range of sensory modalities e.g. temperature or light intensity. Interpolation can be used(More)