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Through adulthood, the rodent subventricular zone (SVZ) stem cell niche generates new olfactory bulb interneurons. We had previously reported that the number of new neurons produced in the SVZ declines through aging; however, age-related changes attributable specifically to the SVZ neural stem cell (NSC) population have not been fully characterized. Here,(More)
This paper describes the rationale, design and implementation of a Reconfigurable Attack-Defend Instructional Computing Laboratory (RADICL). Topics covered include the ethical and pedagogical considerations for creating and using a lab that instructs and develops not only student's abilities to secure a system, but also their ability to attack a system. An(More)
The management of secure communication among groups of participants requires a set of secure and efficient operations. In this paper we extend existing work to present a Communication–Computation Efficient Group Key Algorithm (CCEGK) designed to provide both efficient communication and computation, addressing performance, security and authentication issues(More)
The secreted peptide hormone hepcidin regulates systemic and local iron homeostasis through degradation of the iron exporter ferroportin. Dysregulation of hepcidin leads to altered iron homeostasis and development of pathological disorders including hemochromatosis, and iron loading and iron restrictive anemias. Therapeutic modulation of hepcidin is a(More)
Iron is an essential dietary element. However, the ability of iron to cycle between oxidized and reduced forms also renders it capable of contributing to free radical formation, which can have deleterious effects, including promutagenic effects that can potentiate tumor formation. Dysregulation of iron metabolism can increase cancer risk and promote tumor(More)
To preserve critical energy control functions while under attack, it is necessary to perform comprehensive analysis on the root cause and impact of an ongoing cyber intrusion without sacrificing the availability of energy delivery. In this position paper, we present a proof of concept of an intrinsically resilient energy control system, with the ultimate(More)
In order to provide a safe and separate system on which to train, test, and teach computer and network security, The reconfigurable network system is relatively inexpensive to build even through it supports several operating systems in a myriad of network topographies. University faculty and students can use the laboratory to understand attack scripts and(More)
Duodenal cytochrome b (DCYTB) is a ferrireductase that functions together with divalent metal transporter 1 (DMT1) to mediate dietary iron reduction and uptake in the duodenum. DCYTB is also a member of a 16-gene iron regulatory gene signature (IRGS) that predicts metastasis-free survival in breast cancer patients. To better understand the relationship(More)