David Malfair

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Glomus tumours are uncommon benign neoplasms characterised by the proliferation of modified smooth muscle cells known as glomus cells. Glomus tumours are well described in the extremities, particularly in the sub-ungual region and MRI is well established as the investigation of choice. However, a significant proportion of glomus tumours are extra-digital,(More)
STUDY DESIGN Prospective diagnostic imaging study. OBJECTIVE To determine the accuracy of magnetic resonance imaging (MRI) in diagnosing injury of the posterior ligamentous complex (PLC) in patients with thoracolumbar trauma. SUMMARY OF BACKGROUND DATA Treatment decisions in thoracolumbar injury patients are currently based on the status of the PLC. It(More)
The objective of this study was to optimize ankle joint MR imaging in volunteers at 1.5 Tesla (T) and 3.0 T, and to compare these optimized sequences concerning image quality and performance in assessing cartilage, ligament and tendon pathology in fresh human cadaver specimens. Initially our clinical ankle protocol consisting of T1-weighted (-w),(More)
The normal intestinal epithelium provides a barrier relatively impermeable to luminal constituents. However, patients with inflammatory bowel disease experience enhanced intestinal permeability that correlates with the degree of injury. IL-10 gene-deficient mice were studied to determine whether increased intestinal permeability occurs as a primary defect(More)
Degenerative changes of the spine may involve the disc space, the facet joints, or the supportive and surrounding soft tissues. MR imaging is ideally suited for delineating the presence, extent, and complications of degenerative spinal disease. Other imaging modalities such as radiography, myelography, and CT may provide complimentary information in(More)
The cyamella is infrequently encountered in humans with only a handful of reports in the literature describing its appearance on radiographs, CT, and MRI [1, 2]. It is occasionally referred to as the popliteal fabella or the fabella distalis. It is typically located within the tendon or, occasionally, the myotendinous junction of the popliteus muscle, which(More)
Crohn's disease is a chronic disease characterized by oxidant-induced tissue injury and increased intestinal permeability. A consequence of oxidative damage is the accumulation of DNA strand breaks and activation of poly(ADP-ribose) polymerase (PARP), which subsequently catalyzes ADP-ribosylation of target proteins. In this study, we assessed the role of(More)
PURPOSE To compare magnetic resonance imaging of the ankle joint at 1.5 Tesla (T) and 3.0 T in the assessment of cartilage and ligament pathology in fresh human cadaver specimens. MATERIALS AND METHODS The study was performed in line with institutional and legislative requirements; all donors had dedicated their body for educational and research purposes(More)
The frequency and variety of spinal instrumentation has increased tremendously over the past 100 years, and imaging plays an important role in evaluating the postoperative spine. Although assessment of spinal hardware often involves a multimodality approach, plain radiographs are the most commonly used modality, given accessibility, cost, relatively low(More)