David Ma Francis

Learn More
Stressful events during periods of drug abstinence likely contribute to relapse in cocaine-dependent individuals. Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing factor (CRF) responsiveness. This study examined stressor- and CRF-induced cocaine seeking and other(More)
The loss of control over cocaine use and persistently heightened susceptibility to drug relapse that define human cocaine addiction are consequences of drug-induced neuroplasticity and can be studied in rats self-administering cocaine under conditions of daily long access (LgA) as escalating patterns of drug intake and heightened susceptibility to(More)
Data suggest that blood transfusion can cause immunosuppression. The incidence of recurrence of tumours was examined retrospectively in patients who had undergone potentially curative operations for cancer of the colon during 1970-81. Tumours recurred in six of 68 patients (9%) who had not been given transfusions and in 56 of 129 patients (43%) who had (p(More)
A randomized double-blind study was performed to elucidate the interrelationships among volume, concentration, and dosage of bupivacaine administered intrathecally. Sixty male patients between the ages of 40 and 80 years having transurethral surgery in the lithotomy position were studied using 10-, 15-, and 20-mg doses of glucose-free bupivacaine as either(More)
AIM To investigate the tissue specificity of a novel monoclonal antibody raised to a tissue fraction of normal human liver and which identified certain cells of gastric and duodenal mucosa. METHODS A total of 155 samples of various tissues obtained from 100 surgical specimens were fixed in cold ethanol-paraformaldehyde, embedded in paraffin wax, and 3(More)
BACKGROUND A new three-layered cast polyurethane vascular access graft (Thoratec VAG) is the most recent addition to the list of materials used in the search for the perfect prosthetic graft material for haemodialysis vascular access. Despite its use in 23 countries, a clinical assessment has not been published. METHODS An independent retrospective(More)
A case of intercostal herniation of the greater omentum occurring 36 years after a penetrating chest injury is presented. The hernia was successfully treated by operative reduction and repair of the diaphragm and chest wall. This rare complication of thoracic injury is discussed and the literature reviewed.
An experimental model of subarachnoid haemorrhage has been developed in the baboon to allow accurate measurements of the changes of ICP and cortical bloodflow, auto-regulatiion, reactivity changes and central conduction time extending over a period up to three months. Twelve hydrogen electrodes were implanted in pairs allowing CBF measurements in standard(More)