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  • Erik J. Eide, Erica L Vielhaber, William A Hinz, David M. Virshup
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2002 (First Publication: 10 May 2002)
  • The serine/threonine protein kinase casein kinase I ε (CKIε) is a key regulator of metazoan circadian rhythm. Genetic and biochemical data suggest that CKIε binds to and phosphorylates the PERIODContinue Reading
  • Brent McCright, A M Rivers, S Audlin, David M. Virshup
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1996 (First Publication: 6 September 1996)
  • Protein phosphatase 2A is a heterotrimeric protein serine/threonine phosphatase consisting of a 36-kDa catalytic C subunit, a 65-kDa structural A subunit, and a variable regulatory B subunit. The BContinue Reading
  • Erica L Vielhaber, Eugen Eide, Andrew Rivers, Zhancheng Gao, David M. Virshup
  • Medicine, Biology
  • Molecular and cellular biology
  • 2000 (First Publication: 1 July 2000)
  • The molecular oscillator that keeps circadian time is generated by a negative feedback loop. Nuclear entry of circadian regulatory proteins that inhibit transcription from E-box-containing promotersContinue Reading
  • Qing-Jun Meng, Larisa Logunova, +15 authors Andrew S Loudon
  • Medicine, Biology
  • Neuron
  • 2008 (First Publication: 1 April 2008)
  • The intrinsic period of circadian clocks is their defining adaptive property. To identify the biochemical mechanisms whereby casein kinase1 (CK1) determines circadian period in mammals, we createdContinue Reading