• Publications
  • Influence
Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF
DURING normal development of the vertebrate nervous system, large numbers of neurons in the central and peripheral nervous system undergo naturally occurring cell death1. For example, about half ofExpand
  • 689
  • 27
Complete Dissociation of Motor Neuron Death from Motor Dysfunction by Bax Deletion in a Mouse Model of ALS
The death of cranial and spinal motoneurons (MNs) is believed to be an essential component of the pathogenesis of amyotrophic lateral sclerosis (ALS). We tested this hypothesis by crossingExpand
  • 347
  • 22
  • PDF
Glial Cell Line-Derived Neurotrophic Factor and Developing Mammalian Motoneurons: Regulation of Programmed Cell Death Among Motoneuron Subtypes
Because of discrepancies in previous reports regarding the role of glial cell line-derived neurotrophic factor (GDNF) in motoneuron (MN) development and survival, we have reexamined MNs inExpand
  • 162
  • 11
  • PDF
Exogenous Delivery of Heat Shock Protein 70 Increases Lifespan in a Mouse Model of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder that results in the progressive loss of motoneurons (MNs) in the CNS. Several survival and death mechanisms of MNsExpand
  • 126
  • 11
  • PDF
Characterization of early pathogenesis in the SOD1G93A mouse model of ALS: part II, results and discussion
Pathological events are well characterized in amyotrophic lateral sclerosis (ALS) mouse models, but review of the literature fails to identify a specific initiating event that precipitates diseaseExpand
  • 113
  • 11
Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death
DURING normal vertebrate development, about half of spinal motoneurons are lost by a process of naturally occurring or programmed cell death1,2. Additional developing motoneurons degenerate after theExpand
  • 439
  • 9
Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro
Members of the CED-3/interleukin-1 beta-converting enzyme (ICE) protease family have been implicated in cell death in both invertebrates and vertebrates. In this report, we show that peptideExpand
  • 313
  • 9
Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases
An analysis of programmed cell death of several populations of developing postmitotic neurons after genetic deletion of two key members of the caspase family of pro-apoptotic proteases, caspase-3 andExpand
  • 219
  • 8
  • PDF
Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor.
During development of the nervous system, neurons in many regions are overproduced by proliferation, after which the excess cells are eliminated by cell death. The survival of only a proportion ofExpand
  • 444
  • 7
Naturally-occurring neuron death in the ciliary ganglion of the chick embryo following removal of preganglionic input: evidence for the role of afferents in ganglion cell survival
With only a few exceptions, most investigations of the mechanisms involved in naturally-occurring neuron death have focused on interactions between neurons and their targets, with much less attentionExpand
  • 149
  • 7
  • PDF