Learn More
Architectures for software use rich abstractions and idioms to describe system components, the nature of interactions among the components, and the patterns that guide the composition of components into systems. These abstractions are higher-level than the elements usually supported by programming languages and tools. They capture packaging and interaction(More)
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isooxazole) receptors, a major subtype of ionotropic glutamate receptors (iGluRs), mediate the majority of the fast communication between neurons, and the activity-dependent trafficking of AMPA receptors at synapses plays a role in mammalian learning and memory. Here we describe the design, synthesis, and evaluation of(More)
Tuberous sclerosis (TSC) is an autosomally dominant neurocutaneous disease notable for its high comorbidity with autism in human patients. Studies of murine models of tuberous sclerosis have found defects in cognition and learning, but thus far have not uncovered deficits in social behaviors relevant to autism. To explore social communication and(More)
  • David R Kincaid, John R Respess, David M Young, Austin, Roger G Grimes
  • 1996
ITPACK 2C is a collection of seven FORTRAN subroutines for solving large sparse linear systems by adaptive accelerated iterative algorithms. Basic iterative procedures, such as the Jacobi method, the Successive Overrelaxation method, the Symmetric Successive Overrelaxation method, and the RS method for the reduced system are combined , where possible, with(More)
Rapamycin, a specific inhibitor for mTOR complex 1, is an FDA-approved immunosuppressant for organ transplant. Recent developments have raised the prospect of using rapamycin to treat cancer or diabetes and to delay aging. It is therefore important to assess how rapamycin treatment affects glucose homeostasis. Here, we show that the same rapamycin treatment(More)
Genotypic and phenotypic analyses were carried out to clarify the taxonomic position of the naturally transformable Acinetobacter sp. strain ADP1. Transfer tDNA-PCR fingerprinting, 16S rRNA gene sequence analysis, and selective restriction fragment amplification (amplified fragment length polymorphism analysis) indicate that strain ADP1 and a second(More)
The regulated recruitment and differentiation of multipotent bone marrow-derived cells (BMDCs) to sites of injury are critical for efficient wound healing. Previously we demonstrated that sustained expression of HOXA3 both accelerated wound healing and promoted angiogenesis in diabetic mice. In this study, we have used green fluorescent protein-positive(More)