David M. Wheeler

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Aims: To evaluate the benefits and harms of treatments for vesicoureteric reflux in children. Methods: Meta-analyses of randomised controlled trials using a random effects model. Main outcome measures were incidence of urinary tract infection (UTI), new or progressive renal damage, renal growth, hypertension, and glomerular filtration rate. Results: Eight(More)
The Java (TM) Virtual Machine is being used more frequently as the basic engine behind dynamic web services. With the proliferation of network attacks on these network resources, much work has been done to provide security for the network environment. Continuing work on firewalls, intrusion detection, and even access control have provided numerous insights(More)
Salicylic acid (SA) is an important signaling molecule in local and systemic plant resistance. Following infection by microbial pathogens and the initial oxidative burst in plants, SA accumulation functions in the amplification of defense gene expression. Production of pathogenesis-related proteins and toxic antimicrobial chemicals serves to protect the(More)
Prenatal screening for fetal abnormalities in an accepted part of modern obstetric management. Improvements on current screening procedures need to address increased diagnostic efficacy and earlier diagnosis. This study evaluates diagnostic efficacy of PAPP-A and F beta-hCG in the detection of first trimester pregnancy abnormalities, including Down syndrome(More)
Screening for aneuploidy using maternal age has a low detection rate and high false positive rate. Second trimester maternal serum screening increases trisomy 21 detection and decreases the false positive rate. First trimester screening would enable definitive diagnosis with chorionic villus sampling, and simple surgical termination of affected pregnancies(More)
In this issue of RESPIRATORY CARE, Allan and colleagues report on the safety of high-frequency chest-wall compression (HFCWC, with The Vest, Hill-Rom, St Paul, Minnesota) in the 48 hours following thoracic surgery.1 The study is long overdue and is the first examination of the general safety and hemodynamic consequences of HFCWC in a patient population that(More)
In this issue of RESPIRATORY CARE, Allan and colleagues report on the safety of high-frequency chest-wall compression (HFCWC, with The Vest, Hill-Rom, St Paul, Minnesota) in the 48 hours following thoracic surgery.1 The study is long overdue and is the first examination of the general safety and hemodynamic consequences of HFCWC in a patient population that(More)
Intensive management of the sick neonate demands aggressive monitoring involving access to the arterial system. This is usually accomplished using an umbilical artery catheter. Complications of this technique are well recognised and include infection, catheter embolism, neurological complications, necrotising enterocolitis, hypertension, arterial(More)
UNLABELLED The purpose of this study was to evaluate the performance of dimercaptosuccinic acid (DMSA) scintigraphy in the diagnosis of acute pyelonephritis and to compare the test performance of the standard technique, planar DMSA, with the newly introduced technique, SPECT DMSA. METHODS All published animal studies in which DMSA scintigraphy was(More)
BACKGROUND Teamwork promotes enhanced outcomes in various business sectors but can be hampered when there are organizational "silos." This study describes an intervention that fostered teamwork among 4 separate respiratory therapy (RT) departments within a single hospital. METHODS An initial retreat of leaders of the 4 RT groups indicated a common goal of(More)